Polarity proteins as regulators of cell junction complexes: implications for breast cancer.
Polarity proteins as regulators of cell junction complexes: implications for breast cancer.
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DOI：
10.1016/j.pharmthera.2013.02.004
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发表时间：
2013-06
影响因子：
13.5
通讯作者：
Talhouk, Rabih
中科院分区：
文献类型：
--
作者：
Bazzoun, Dana;Lelievre, Sophie;Talhouk, Rabih
多细胞生物体的上皮细胞具有明确的结构，称为极性，协调基本细胞特征的调节。极性蛋白质与蛋白质复合体紧密相连，形成紧密、粘连和缝隙连接；它们有助于这些细胞-细胞连接在细胞内的适当定位和组装，从而促进功能组织的形成。在正常和癌症的情况下，细胞-细胞连接的建立和极性的建立都与上皮修饰的调节有关。揭示细胞-细胞连接和上皮极化建立的机制，以及它们如何与微环境相互作用，直接组织细胞和组织，为癌症治疗的发展开辟了新的场所。在这篇综述中，我们主要关注乳腺上皮，以强调在正常和癌症环境中，极性和细胞-细胞连接蛋白如何相互作用，以调节主要的细胞机制，如迁移。鉴于越来越多的证据表明组织极性调节染色质功能，讨论了这些蛋白质对负责将细胞重置为肿瘤发生的表观遗传机制的影响。最后，我们对最近针对细胞-细胞连接相关蛋白的乳腺癌治疗方法进行了概述。
The epithelium of multicellular organisms possesses a well-defined architecture, referred to as polarity that coordinates the regulation of essential cell features. Polarity proteins are intimately linked to the protein complexes that make the tight, adherens and gap junctions; they contribute to the proper localization and assembly of these cell-cell junctions within cells and consequently to functional tissue organization. The establishment of cell-cell junctions and polarity are both implicated in the regulation of epithelial modifications in normal and cancer situations. Uncovering the mechanisms through which cell-cell junctions and epithelial polarization are established and how their interaction with the microenvironment direct cell and tissue organization has opened new venues for the development of cancer therapies. In this review, we focus on the breast epithelium to highlight how polarity and cell-cell junction proteins interact together in normal and cancerous contexts to regulate major cellular mechanisms such as migration. The impact of these proteins on epigenetic mechanisms responsible for resetting cells towards oncogenesis is discussed in light of increasing evidence that tissue polarity modulates chromatin function. Finally, we give an overview of recent breast cancer therapies that target proteins involved in cell-cell junctions.
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DOI：
10.1186/1478-811x-7-4
发表时间：
2009-03-12
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Dbouk HA;Mroue RM;El-Sabban ME;Talhouk RS
通讯作者：
Talhouk RS
影响因子：
8.4
作者：
FIDLER, IJ
通讯作者：
FIDLER, IJ
影响因子：
6.2
作者：
Breen, Nancy;Gentleman, Jane F.;Schiller, Jeannine S.
通讯作者：
Schiller, Jeannine S.
影响因子：
64.8
作者：
Betschinger, J;Mechtler, K;Knoblich, JA
通讯作者：
Knoblich, JA
DOI：
10.1126/science.1199633
发表时间：
2011-03-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dickinson DJ;Nelson WJ;Weis WI
通讯作者：
Weis WI