A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation.
A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation.
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DOI：
10.3390/antiox9090886
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发表时间：
2020-09-18
期刊：
影响因子：
--
通讯作者：
Castell L
中科院分区：
文献类型：
--
作者：
Taherkhani S;Suzuki K;Castell L
炎症细胞因子的过度释放和氧化应激（OS）是慢性疾病发病的触发因素。可以确保人类健康的因素之一是定期的身体活动。这种类型的活动可以增强免疫功能，并显着防止细胞因子反应和OS的传播。然而，如果不规律地进行剧烈的体力活动，不仅不健康，还会导致肌肉损伤、OS和炎症。本文就运动对细胞因子和OS的影响作一综述。此外，它主要集中在运动过程中肌肉代谢和损伤产生的活性氧和氮（RONS）的作用以及抗氧化剂补充剂的调节作用。此外，还分析了年龄、性别和运动方案类型（训练量、持续时间和强度）等因素的影响。抗氧化剂补充剂对改善OS和炎性细胞因子的作用有些模糊。需要更多的研究来了解这个问题，更详细地考虑训练水平，健康状况，年龄，性别，疾病和运动方案类型等因素。
Excessive release of inflammatory cytokines and oxidative stress (OS) are triggering factors in the onset of chronic diseases. One of the factors that can ensure health in humans is regular physical activity. This type of activity can enhance immune function and dramatically prevent the spread of the cytokine response and OS. However, if physical activity is done intensely at irregular intervals, it is not only unhealthy but can also lead to muscle damage, OS, and inflammation. In this review, the response of cytokines and OS to exercise is described. In addition, it is focused predominantly on the role of reactive oxygen and nitrogen species (RONS) generated from muscle metabolism and damage during exercise and on the modulatory effects of antioxidant supplements. Furthermore, the influence of factors such as age, sex, and type of exercise protocol (volume, duration, and intensity of training) is analyzed. The effect of antioxidant supplements on improving OS and inflammatory cytokines is somewhat ambiguous. More research is needed to understand this issue, considering in greater detail factors such as level of training, health status, age, sex, disease, and type of exercise protocol.
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