Computation of transient flow rates in passive pumping micro-fluidic systems.
Computation of transient flow rates in passive pumping micro-fluidic systems.
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DOI：
10.1039/b808660e
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发表时间：
2009-01-07
期刊：
影响因子：
6.1
通讯作者：
Lindner E
中科院分区：
文献类型：
--
作者：
Chen IJ;Eckstein EC;Lindner E
被动流动微流体系统中微通道内的运动可以通过适当的设计来控制，并通过仔细的建模来估计。我们报告的方法来描述作为时间的函数的流量在被动泵驱动的微流体系统。该模型考虑了小液滴中存在的表面能，这促使它们收缩并诱导流动。液滴几何形状由微流体系统几何形状和液滴通道接触区域的亲水性控制，使得液滴横截面的弦在流体被泵送时受到限制。该模型采用界面热力学和哈根-普瓦莱方程计算微通道中的流量。现有的分析考虑了样品体积和诱导流速、入口和出口处的液滴表面能以及流动阻力之间的理论关系。该模型提供了更具体的信息的影响，实验条件的流量计算。该模型在四组实验中进行了验证。具有1.8 mm直径、疏水或亲水入口、5.0或10.0 mm通道长度和2.5或3.3 mm直径储存器端口的被动泵提供85 nL/sec和196 nL/sec之间的初始流速。
Motion in micro-channels of passive flow micro-fluidic systems can be controlled by proper design and estimated by careful modeling. We report on methods to describe the flow rate as function of time in a passive pump driven micro-fluidic systems. The model considers the surface energy present in small droplets, which prompts their shrinkage and induces flow. The droplet geometries are controlled by the micro-fluidic system geometry and hydrophilicity of the droplet channel contact area so that the chord of the droplet’s cross section is restrained as the fluid is pumped. The model uses interfacial thermodynamics and the Hagen-Poiseuille equation for calculating the flow rate in micro-channels. Existing analyses consider the theoretical relationships among sample volume and induced flow rate, surface energy of the drops at the entrance and exit ports, and the resistance to flow. This model provides more specific information on the influence of the experimental conditions in computations of the flow rate. The model was validated in four sets of experiments. Passive pumps with 1.8 mm diameter, hydrophobic or hydrophilic entry ports, 5.0 or 10.0 mm channel length, and 2.5 or 3.3 mm diameter reservoir ports provided initial flow rates between 85 nL/sec and 196 nL/sec.
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