Recent advancements for the evaluation of anti-viral activities of natural products.
Recent advancements for the evaluation of anti-viral activities of natural products.
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DOI：
10.1016/j.nbt.2009.03.007
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发表时间：
2009-06
影响因子：
5.4
通讯作者：
Khan MT
中科院分区：
文献类型：
--
作者：
Chattopadhyay D;Sarkar MC;Chatterjee T;Sharma Dey R;Bag P;Chakraborti S;Khan MT
近年来，新型抗病毒药物的开发取得了重大进展。这些新开发的药物大多属于核苷类似物、胸苷激酶依赖性核苷酸类似物和特异性病毒酶抑制剂三类化合物。人们已经发现，天然产物，如植物提取物，植物衍生化合物（植物化学品）等，以及传统药物，如阿育吠陀，传统中药（TCM），脉轮药物等，是潜在的和新的抗病毒药物的潜在来源，基于不同的体外和体内方法。在本章中，我们将讨论在药物发现过程中用于抗病毒药物的潜在候选药物的一些重要方法。主要结论是天然产物是新型抗病毒药物的最重要来源之一。
Significant progress has been achieved for the development of novel anti-viral drugs in the recent years. Large numbers of these newly developed drugs belong to three groups of compounds, nucleoside analogues, thymidine kinase-dependent nucleotide analogues and specific viral enzyme inhibitors. It has been found that the natural products, like plant extract, plant-derived compounds (phytochemicals) and so on, as well as traditional medicines, like Ayurvedic, traditional Chinese medicine (TCM), Chakma medicines and so on, are the potential sources for potential and novel anti-viral drugs based on different in vitro and in vivo approaches. In this chapter some of these important approaches utilised in the drug discovery process of potential candidate(s) for anti-viral agents are being discussed. The key conclusion is that natural products are one of the most important sources of novel anti-viral agents.
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DOI：
10.1016/0147-9571(88)90039-2
发表时间：
1988-01-01
影响因子：
2
作者：
BARRAT, J;BARRAT, MJ;AUBERT, MFA
通讯作者：
AUBERT, MFA
影响因子：
3.8
作者：
Brussel, A;Mathez, D;Leibowitch, J
通讯作者：
Leibowitch, J
影响因子：
6.4
作者：
Crowe, JE;Bui, PT;Murphy, BR
通讯作者：
Murphy, BR
DOI：
10.1099/00221287-6-1-2-74
发表时间：
1952-01-01
期刊：
JOURNAL OF GENERAL MICROBIOLOGY
影响因子：
--
作者：
CHANTRILL, BH;COULTHARD, CE;PYLE, AH
通讯作者：
PYLE, AH
影响因子：
3.3
作者：
Chattopadhyay, D.;Arunachalam, G.;Bhattacharya, S. K.
通讯作者：
Bhattacharya, S. K.