Hypogonadal Men with Higher Body Mass Index have Higher Bone Density and Better Bone Quality but Reduced Muscle Density.
Hypogonadal Men with Higher Body Mass Index have Higher Bone Density and Better Bone Quality but Reduced Muscle Density.
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体重指数较高的性交男性的骨密度更高，骨质质量更好，但肌肉密度降低。
DOI：
10.1007/s00223-017-0316-x
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发表时间：
2017-12
影响因子：
4.2
通讯作者：
Armamento-Villareal R
中科院分区：
文献类型：
--
作者：
Aguirre LE;Colleluori G;Dorin R;Robbins D;Chen R;Jiang B;Qualls C;Villareal DT;Armamento-Villareal R
虽然性腺功能减退症是骨丢失和骨折的危险因素，但经典性腺功能减退症和肥胖性性腺功能减退症的不同病因和激素谱可能会导致肌肉骨骼谱的不同。这是一项针对40至74岁性腺功能减退男性的横断面研究。研究结果包括：用双能X线骨密度仪测量胫骨的面积骨密度(ABMD)和体成分；用外周定量CT测量胫骨的体积骨密度(VBMD)和软组织成分。对骨折风险评估工具(FRAX)进行评分。测定睾酮、雌二醇、黄体生成素、卵泡刺激素、性激素结合球蛋白、C-端肽、骨钙素和硬化素。我们将人群分为体重指数亚组：组1：体重指数30；组2：体重指数≥30~35；组3：体重指数≥35 kg/m2。105人被征召入伍。随着BMI的增加，脊柱和髋部的aBMD以及胫骨4%处的总vBMD和骨小梁vBMD显著增加。38%胫骨皮质厚度(330.7±5 3.2,343.3±35.4,358.7±38.2 mm，p=0.0 4)和皮质面积(5.3±0.7，5.5±0.6，5.7±0.6 mm，p=0.0 1)均随体重指数的增加而增加。绝对瘦质量随BMI增加而增加，但瘦质量百分比和肌肉密度(分别为70.2±5.0、71.3±6.4和67.1±5.1 mg/cm3；第1、2、3组)在第3组中最低。严重肥胖的性腺功能低下男性虽然骨密度和骨质量较好，但肌肉密度降低，其意义尚待确定。
Although hypogonadism is a risk factor for bone loss and fractures, the different etiopathophysiology and hormonal profile of classical and obesity-induced hypogonadism may lead to differences in musculoskeletal profile. This is a cross-sectional study of hypogonadal men between 40 and 74 years old. Our outcomes include: areal bone mineral density (aBMD) and body composition by dual-energy X-ray absorptiometry; volumetric BMD (vBMD) and soft tissue composition of the tibia by peripheral quantitative computed tomography. Fracture risk assessment tool (FRAX) scores were evaluated. Testosterone, estradiol, luteinizing hormone, follicle stimulating hormone, sex hormone-binding globulin, C-telopeptide, osteocalcin, and sclerostin were measured. We divided the population into subgroups of BMI: group 1: BMI < 30; group 2: BMI ≥ 30 to <35 and group 3: BMI ≥ 35 kg/m2. One-hundred five men were enrolled. Spine and hip aBMD, and total and trabecular vBMD at the 4% tibia significantly increased with increasing BMI. Cortical thickness (330.7 ± 53.2, 343.3 ± 35.4, and 358.7 ± 38.2 mm, p = 0.04; groups 1, 2 and 3, respectively) and cortical area (5.3 ± 0.7, 5.5 ± 0.6, and 5.7 ± 0.6 mm, p = 0.01; groups 1, 2 and 3, respectively) at 38% tibia increased with increasing BMI. While absolute lean mass increased with increasing BMI, % lean mass and muscle density (70.2 ± 5.0, 71.3 ± 6.4, and 67.1 ± 5.1 mg/cm3; groups 1, 2 and 3, respectively) were lowest in group 3. Although severely obese hypogondal men have better BMD and bone quality, they have reduced muscle density, the significance of which remains to be determined.
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影响因子：
5.8
作者：
Barrett-Connor, E;Mueller, JE;Sartoris, DJ
通讯作者：
Sartoris, DJ
影响因子：
3.3
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Armamento-Villareal, Reina
影响因子：
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作者：
Lamm, Steven;Chidakel, Aaron;Bansal, Rohan
通讯作者：
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影响因子：
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作者：
KLEY, HK;DESELAERS, T;KRUSKEMPER, HL
通讯作者：
KRUSKEMPER, HL