Accessing microfluidics through feature-based design software for 3D printing.
Accessing microfluidics through feature-based design software for 3D printing.
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DOI：
10.1371/journal.pone.0192752
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Retterer ST
中科院分区：
文献类型：
--
作者：
Shankles PG;Millet LJ;Aufrecht JA;Retterer ST
几十年来，添加剂制造一直是产品开发管道的基石，在创造功能和美容原型方面发挥着至关重要的作用。近年来，分布式和开源制造的前景有了巨大的增长。这一增长得益于可打印材料、低成本打印机和致力于平台开发的社区的不断扩大。微流控领域抓住了这一机会，将3D打印集成到用于创建新型流体架构的制造策略套件中。在实验室中实施这些策略的快速周转时间和低成本使3D打印成为传统微米和纳米制造技术的有吸引力的替代方案。在这项工作中，使用混合3D打印-软光刻方法生产多个微流控体系结构，并证明了能够利用层流特性的通道尺寸快速制造器件。这里概述的制造过程是通过实施定制设计软件和集成切片器程序来支持的，该程序取代了不太直观的计算机辅助设计和切片器软件工具。在程序中，通过组装参数化的微流控构件来设计器件。通过一个梯度发生器和两个液滴发生器的设计，演示了3D打印器件的制造工艺和流动控制。对打印过程的精确控制使3D微流体只需一步即可打印出来，方法是将桥结构挤压到同一平面上的“跳跃”通道。这一战略被证明与传统的纳米制造战略相结合，以简化兼具纳米级特征和3D打印微流体的平台的操作。
Additive manufacturing has been a cornerstone of the product development pipeline for decades, playing an essential role in the creation of both functional and cosmetic prototypes. In recent years, the prospects for distributed and open source manufacturing have grown tremendously. This growth has been enabled by an expanding library of printable materials, low-cost printers, and communities dedicated to platform development. The microfluidics community has embraced this opportunity to integrate 3D printing into the suite of manufacturing strategies used to create novel fluidic architectures. The rapid turnaround time and low cost to implement these strategies in the lab makes 3D printing an attractive alternative to conventional micro- and nanofabrication techniques. In this work, the production of multiple microfluidic architectures using a hybrid 3D printing-soft lithography approach is demonstrated and shown to enable rapid device fabrication with channel dimensions that take advantage of laminar flow characteristics. The fabrication process outlined here is underpinned by the implementation of custom design software with an integrated slicer program that replaces less intuitive computer aided design and slicer software tools. Devices are designed in the program by assembling parameterized microfluidic building blocks. The fabrication process and flow control within 3D printed devices were demonstrated with a gradient generator and two droplet generator designs. Precise control over the printing process allowed 3D microfluidics to be printed in a single step by extruding bridge structures to ‘jump-over’ channels in the same plane. This strategy was shown to integrate with conventional nanofabrication strategies to simplify the operation of a platform that incorporates both nanoscale features and 3D printed microfluidics.
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影响因子：
3.7
作者：
Morgan AJ;Hidalgo San Jose L;Jamieson WD;Wymant JM;Song B;Stephens P;Barrow DA;Castell OK
通讯作者：
Castell OK
3D打印的微流体。
DOI：
10.1002/anie.201504382
发表时间：
2016-03-14
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Au AK;Huynh W;Horowitz LF;Folch A
通讯作者：
Folch A
影响因子：
6.1
作者：
Atencia, Javier;Cooksey, Gregory A.;Locascio, Laurie E.
通讯作者：
Locascio, Laurie E.
影响因子：
6.1
作者：
Au AK;Bhattacharjee N;Horowitz LF;Chang TC;Folch A
通讯作者：
Folch A
影响因子：
7.4
作者：
Anderson, JR;Chiu, DT;Whitesides, GM
通讯作者：
Whitesides, GM