Total-Body PET Kinetic Modeling and Potential Opportunities Using Deep Learning.

Total-Body PET Kinetic Modeling and Potential Opportunities Using Deep Learning.
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DOI:
10.1016/j.cpet.2021.06.009
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发表时间:
2021-10
期刊:
影响因子:
2.6
通讯作者:
Wang G
Wang G
中科院分区:
其他
文献类型:
--
作者:
Wang Y;Li E;Cherry SR;Wang G

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The uEXPLORER total-body PET/CT system provides a very high level of detection sensitivity and simultaneous coverage of the entire body for dynamic imaging for quantification of tracer kinetics. This paper describes the fundamentals and potential benefits of total-body kinetic modeling and parametric imaging focusing on the noninvasive derivation of blood input function, multiparametric imaging, and high-temporal resolution kinetic modeling. Along with its attractive properties, total-body kinetic modeling also brings significant challenges, such as the large scale of total-body dynamic PET data, the need for organ and tissue appropriate input functions and kinetic models, and total-body motion correction. These challenges, and the opportunities using deep learning, are discussed.
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