Lung cancer stem cells: progress and prospects.
Lung cancer stem cells: progress and prospects.
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DOI：
10.1016/j.canlet.2012.08.014
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发表时间：
2013-09-10
期刊：
影响因子：
9.7
通讯作者：
Driscoll, Barbara
中科院分区：
文献类型：
--
作者：
Lundin, Amber;Driscoll, Barbara
上皮干细胞对发育过程中的组织生成和损伤后的修复至关重要。在妊娠和出生后阶段，肺的高度分枝和分区组织由多个常驻干细胞/祖细胞群体维持，这些干细胞/祖细胞负责维持肺上皮的动态平衡和损伤修复。虽然无癌基因突变的肺上皮损伤更常见的表现为慢性肺部疾病，但肺癌是全球最常见的死亡形式，对人类健康构成极大的风险。癌症的定义是起源细胞，负责引发疾病。癌症干细胞假说提出，癌症干细胞负责疾病的繁殖、生长和传播，这种干细胞是通过自我更新和产生分化的后代的干细胞样特性来鉴定的。在肺癌中，人们假设癌症干细胞来自几种可能的细胞来源。细支气管肺泡干细胞(BASCs)和肺泡II型上皮细胞(AEC2)，以及表达肿瘤干细胞标志物糖蛋白-1(CD133)或侧群标志物的细胞具有干细胞样的抗损伤和增殖能力，使它们成为潜在的肺癌干细胞储存库。在肺肿瘤细胞中也发现了正常调节胚胎肺发育以及成人组织维持和损伤修复的通路的异常激活，包括Wnt、Hedgehog(HH)和Notch通路。据推测，针对肺癌干细胞利用的干细胞信号通路的肺癌治疗方法可能有助于对抗这种疾病。
Epithelial stem cells are critical for tissue generation during development and for repair following injury. In both gestational and postnatal stages, the highly branched and compartmentalized organization of the lung is maintained by multiple, resident stem/progenitor cell populations that are responsible for the homeostatic maintenance and injury repair of pulmonary epithelium. Though lung epithelial injury in the absence of oncogenic mutation is more commonly expressed as chronic lung disease, lung cancer is the most common form of death worldwide and poses a highly significant risk to human health. Cancer is defined by the cell of origin, responsible for initiating the disease. The Cancer Stem Cell Hypothesis proposes that cancer stem cells, identified by stem-like properties of self-renewal and generation of differentiated progeny, are responsible for propagating growth and spread of the disease. In lung cancer, it is hypothesized that cancer stem cells derive from several possible cell sources. The stem cell-like resistance to injury and proliferative potentials of bronchioalveolar stem cells (BASCs) and alveolar epithelial type II cells (AEC2), as well as cells that express the cancer stem cell marker glycoprotein prominin-1 (CD133) or markers for side populations make them potential reservoirs of lung cancer stem cells. The abnormal activation of pathways that normally regulate embryonic lung development, as well as adult tissue maintenance and injury repair, including the Wnt, Hedgehog (Hh) and Notch pathways, has also been identified in lung tumor cells. It is postulated that therapies for lung cancer that specifically target stem cell signaling pathways utilized by lung cancer stem cells could be beneficial in combating this disease.
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影响因子：
4.3
作者：
Dingli D;Traulsen A;Michor F
通讯作者：
Michor F
DOI：
10.1007/978-1-4614-0899-4_15
发表时间：
2012-01-01
期刊：
NOTCH SIGNALING IN EMBRYOLOGY AND CANCER
影响因子：
--
作者：
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通讯作者：
Dang, Thao P.
影响因子：
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作者：
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通讯作者：
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影响因子：
5.8
作者：
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通讯作者：
Weeraratna, Ashani T.
影响因子：
9.7
作者：
Chi, Sumin;Huang, Shuhong;Xie, Jingwu
通讯作者：
Xie, Jingwu