Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray.
Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray.
复制标题
在环境条件下通过双尖端反应纸喷雾加速丹磺酰氯与苯胺的亲核取代反应。
DOI：
10.1038/s41598-020-78133-4
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发表时间：
2020-12-09
影响因子：
4.6
通讯作者：
Maher S
中科院分区：
文献类型：
--
作者：
Sarih NM;Romero-Perez D;Bastani B;Rauytanapanit M;Boisdon C;Praneenararat T;Tajuddin HA;Abdullah Z;Badu-Tawiah AK;Maher S
纸喷雾电离（PSI）质谱（MS）是通过微滴反应加速进行环境反应监测的新兴工具。PSI-MS用于加速和监测丹磺酰氯与苯胺在乙腈中反应以产生丹磺酰苯胺的时间过程。在本研究中探索了三种不同的PSI安排，代表样品加载和相互作用的替代方法;设计了传统的单尖端以及两种新型设置，双尖端和同轴安排，以限制试剂之间的任何纸上相互作用。使用这些不同的纸配置研究对产物丰度的影响，因为它与微滴行进的时间过程和距离有关。据观察，产品产量增加，在一个给定的距离，然后降低，此后为所有PSI配置。产物（丹磺酰苯胺）的荧光性质用于目视检查在喷涂过程中在纸基材上的反应进程。在各种样品加载方法中，新型双尖端布置显示出增加的产物产率和微滴密度，同时避免试剂之间的任何纸上相互作用。
Paper spray ionization (PSI) mass spectrometry (MS) is an emerging tool for ambient reaction monitoring via microdroplet reaction acceleration. PSI-MS was used to accelerate and monitor the time course of the reaction of dansyl chloride with aniline, in acetonitrile, to produce dansyl aniline. Three distinct PSI arrangements were explored in this study representing alternative approaches for sample loading and interaction; conventional single tip as well as two novel setups, a dual-tip and a co-axial arrangement were designed so as to limit any on-paper interaction between reagents. The effect on product abundance was investigated using these different paper configurations as it relates to the time course and distance of microdroplet travel. It was observed that product yield increases at a given distance and then decreases thereafter for all PSI configurations. The fluorescent property of the product (dansyl aniline) was used to visually inspect the reaction progress on the paper substrate during the spraying process. Amongst the variety of sample loading methods the novel dual-tip arrangement showed an increased product yield and microdroplet density, whilst avoiding any on-paper interaction between the reagents.
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DOI：
10.1007/s13361-014-1029-2
发表时间：
2015-02-01
影响因子：
3.2
作者：
Jjunju, Fred P. M.;Maher, Simon;Cooks, R. Graham
通讯作者：
Cooks, R. Graham
影响因子：
7.4
作者：
Damon, Deidre E.;Yin, Mengzhen;Badu-Tawiah, Abraham K.
通讯作者：
Badu-Tawiah, Abraham K.
影响因子：
9.5
作者：
Dhummakupt, Elizabeth S.;Carmany, Daniel O.;Glaros, Trevor
通讯作者：
Glaros, Trevor
影响因子：
3
作者：
Bain, Ryan M.;Pulliam, Christopher J.;Cooks, R. Graham
通讯作者：
Cooks, R. Graham
影响因子：
2
作者：
Bain, Ryan M.;Pulliam, Christopher J.;Cooks, R. Graham
通讯作者：
Cooks, R. Graham