Tunable plasmonic nanoprobes for theranostics of prostate cancer.
Tunable plasmonic nanoprobes for theranostics of prostate cancer.
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DOI：
10.7150/thno/v01p0003
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发表时间：
2011-01-10
期刊：
影响因子：
12.4
通讯作者：
Lapotko DO
中科院分区：
文献类型：
--
作者：
Lukianova-Hleb EY;Oginsky AO;Samaniego AP;Shenefelt DL;Wagner DS;Hafner JH;Farach-Carson MC;Lapotko DO
治疗应用需要诊断和治疗的耦合，高度的特异性和适应性的交付方法与临床实践兼容。在前列腺癌和基质细胞的异质生物微环境中，研究了等离子体纳米气泡（PNB）选择性靶向和激活的可调物理和生物效应。通过抗体-受体-内吞作用-纳米团簇机制，将金纳米粒子偶联物（NPs）靶向所有细胞，产生NP团簇。细胞内NP团簇在多个波长下同时进行脉冲光学激活，与单独的金NP相比，pnb具有更高的光学对比度和治疗选择性。该机制被称为“彩虹等离子体纳米气泡”。彩虹PNBs的细胞效应在靶细胞中原位调节，从而支持前列腺癌细胞检测和后续引导破坏的治疗算法，而不损害侧支细胞。pnb的特异性和可调性在治疗应用方面很有前景，我们讨论了一种光纤平台，该平台将利用这些特性将治疗工具带入临床。
Theranostic applications require coupling of diagnosis and therapy, a high degree of specificity and adaptability to delivery methods compatible with clinical practice. The tunable physical and biological effects of selective targeting and activation of plasmonic nanobubbles (PNB) were studied in a heterogeneous biological microenvironment of prostate cancer and stromal cells. All cells were targeted with conjugates of gold nanoparticles (NPs) through an antibody-receptor-endocytosis-nanocluster mechanism that produced NP clusters. The simultaneous pulsed optical activation of intracellular NP clusters at several wavelengths resulted in higher optical contrast and therapeutic selectivity of PNBs compared with those of gold NPs alone. The developed mechanism was termed “rainbow plasmonic nanobubbles.” The cellular effect of rainbow PNBs was tuned in situ in target cells, thus supporting a theranostic algorithm of prostate cancer cell detection and follow-up guided destruction without damage to collateral cells. The specificity and tunability of PNBs is promising for theranostic applications and we discuss a fiber optic platform that will capitalize on these features to bring theranostic tools to the clinic.
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