The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.
The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.
复制标题
初始转化细胞的量子可能调节周围正常上皮组织和全身免疫模式引起的局部炎症机制的类型，以阻止肿瘤或进展
DOI：
10.7150/jca.10787
复制
发表时间：
2015
影响因子：
3.9
通讯作者：
Xin Y
中科院分区：
文献类型：
--
作者：
Owusu L;Wang B;Du Y;Li W;Xin Y
免疫/炎症系统潜在地用于阻止、消除或促进肿瘤发展。尽管如此，决定选择的因素还不完全清楚。利用B16/F1同基因野生型模型，我们评估了初始转化细胞密度对明显肿瘤发展的重要性，正常肿瘤邻近上皮组织（NTAT）中炎症介质的分子趋势，以及这些局部事件如何在宿主中系统地反映。在至少45天、最多90天的观察期内，只有接种了超过1× 103个细胞的癌细胞的小鼠才出现明显的肿瘤。免疫印迹显示，在非荷瘤小鼠的NTAT中，IL-1β、IFN-γ以及HMGB 1的全巯基和二硫键形式早期、强烈和短暂存在。然而，所有巯基形式的HMGB 1和延迟，但异常的IL-6表达的特点慢性炎症在荷瘤宿主。这些局部上皮组织事件独特地反映在宿主的全身性细胞因子动态中，其中稳定的Th 1/Th 2特征（IFN-γ/ IL-4）与早期Th 1细胞极化（IL-12/ IL-4）偶联在非肿瘤宿主中得到证实，但在肿瘤宿主中高度波动的Th 1/Th 2谱，甚至在肿瘤变得明显之前。这假设转化细胞的物理量子可以自发地产生或在位点处累积，这在协调局部上皮组织类型和肿瘤进展或停滞所必需的全身免疫/炎症反应的机制中可能是至关重要的。
The immune/ inflammation system potentially serves to arrest, eliminate or promote tumor development. Nonetheless, factors that dictate the choice are not comprehensively known yet. Using a B16/F1 syngeneic wild type model, we evaluated the essentiality of initial transformed cells' density for overt tumor development, the molecular trends of inflammatory mediators in the normal tumor-adjacent epithelial tissues (NTAT), and how such local events may reflect systematically in the host. Overt tumors developed, within an observatory period of at least 45 days and 90 days at most, only in mice inoculated with cancer cells above a limiting threshold of 1× 103 cells. Immunoblots showed early, intense and transient presence of IL-1β, IFN-γ, and both the all-thiol and disulfide forms of HMGB1 in the NTAT of non-tumor bearing mice. However, all-thiol form of HMGB1 and delayed but aberrant IL-6 expression characterized chronic inflammation in tumor bearing hosts. These local epithelial tissue events uniquely reflected in host's systemic cytokines dynamics where stable Th1/Th2 signature (IFN-γ/ IL-4) coupled with early Th1 cells polarization (IL-12/ IL-4) evidenced in non-tumor hosts but highly fluctuating Th1/ Th2 profile in tumor hosts, even before tumors became overt. This hypothesizes that the physical quantum of transformed cells that may either spontaneously arise or accrue at a locus may be crucial in orchestrating the mechanism for the type of local epithelial tissue and systemic immune/ inflammatory responses essential for tumor progression or arrest.
登录
查看更多内容
影响因子：
11.2
作者：
Held MA;Curley DP;Dankort D;McMahon M;Muthusamy V;Bosenberg MW
通讯作者：
Bosenberg MW
影响因子：
64.8
作者：
GURDON, JB
通讯作者：
GURDON, JB
DOI：
10.1158/1078-0432.ccr-13-0495
发表时间：
2013-08-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Kang R;Zhang Q;Zeh HJ 3rd;Lotze MT;Tang D
通讯作者：
Tang D
抗肿瘤免疫反应的激活和调节性T细胞的降低，并在伴有肿瘤轴承小鼠的inder菌（MIP）治疗中激活。
影响因子：
3.7
作者：
Ahmad F;Mani J;Kumar P;Haridas S;Upadhyay P;Bhaskar S
通讯作者：
Bhaskar S
影响因子：
30.5
作者：
通讯作者：
--