A Single Dose of ChAdOx1 nCoV-19 Vaccine Elicits High Antibody Responses in Individuals with Prior SARS-CoV-2 Infection Comparable to That of Two-Dose-Vaccinated, SARS-CoV-2-Infection-Naïve Individuals: A Longitudinal Study in Ethiopian Health Workers.
A Single Dose of ChAdOx1 nCoV-19 Vaccine Elicits High Antibody Responses in Individuals with Prior SARS-CoV-2 Infection Comparable to That of Two-Dose-Vaccinated, SARS-CoV-2-Infection-Naïve Individuals: A Longitudinal Study in Ethiopian Health Workers.
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一剂Chadox1 NCOV-19疫苗在患有先前SARS-COV-2感染的个体中引起高抗体反应，可与两剂量接种的SARS-COV-2感染 - 没有的个体相当：埃塞俄比亚健康中的纵向研究工人。
DOI：
10.3390/vaccines10060859
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发表时间：
2022-05-27
影响因子：
12.7
通讯作者：
Nishiura, Hiroshi
中科院分区：
文献类型：
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作者：
Ito, Kimihito;Piantham, Chayada;Nishiura, Hiroshi
单剂量COVID-19疫苗（主要是基于mRNA的疫苗）显示在先前感染SARS-CoV-2的个体中诱导强烈的抗体应答，这表明在疫苗供应有限的国家，单剂量疫苗足以满足这些个体的需求。然而，这些重要数据仅限于发达国家。我们对接种ChAdOx 1 nCoV-19疫苗的埃塞俄比亚医护人员进行了一项前瞻性纵向研究。我们比较了39名SARS-CoV-2初治受试者和24名先前感染SARS-CoV-2的受试者（P.I.）的SARS-CoV-2受体结合域（RBD）特异性IgG抗体的几何平均滴度（GMT），在两个疫苗接种后时间点（单剂和两剂疫苗接种后8至12周）接受两剂ChAdOx 1 nCoV-19疫苗的受试者。我们注意到，首次给药后8-12周初治受试者的GMT（1632.16）与P.I.接种疫苗前的参与者。有趣的是，P.I.在第一次（GMT，4913.50 vs. 1632.16）和第二次（GMT，9804.60 vs. 6607.30）接种后，参与者的抗体滴度显著高于未接种的参与者。综上所述，我们的研究结果表明，在先前SARS-CoV-2感染的个体中，单剂量ChAdOx 1 nCoV-19产生的抗体应答与两剂量疫苗接种的初治个体相似，如果不是更高的话。
Single-dose COVID-19 vaccines, mostly mRNA-based vaccines, are shown to induce robust antibody responses in individuals who were previously infected with SARS-CoV-2, suggesting the sufficiency of a single dose for those individuals in countries with limited vaccine supply. However, these important data are limited to developed nations. We conducted a prospective longitudinal study among Ethiopian healthcare workers who received a ChAdOx1 nCoV-19 vaccine. We compared the geometric mean titers (GMTs) of the SARS-CoV-2 receptor-binding domain (RBD)-specific IgG antibodies in 39 SARS-CoV-2 naïve participants and 24 participants previously infected with SARS-CoV-2 (P.I.), who received two doses of ChAdOx1 nCoV-19 vaccine across the two post-vaccination time points (at 8 to 12 weeks post single dose and two dose vaccinations). We noted that the GMT (1632.16) in naïve participants at 8–12 weeks post first dose were comparable to the GMT (1674.94) observed in P.I. participants prior to vaccination. Interestingly, P.I. participants had significantly higher antibody titers compared to naïve participants, after both the first (GMT, 4913.50 vs. 1632.16) and second doses (GMT, 9804.60 vs. 6607.30). Taken together, our findings show that a single ChAdOx1 nCoV-19 dose in previously SARS-CoV-2 infected individuals elicits similar, if not higher, antibody responses to those of two-dose-vaccinated naïve individuals.
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DOI：
10.1056/nejmoa2105000
发表时间：
2021-06-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hacisuleyman E;Hale C;Saito Y;Blachere NE;Bergh M;Conlon EG;Schaefer-Babajew DJ;DaSilva J;Muecksch F;Gaebler C;Lifton R;Nussenzweig MC;Hatziioannou T;Bieniasz PD;Darnell RB
通讯作者：
Darnell RB
DOI：
10.1126/science.abn4947
发表时间：
2022-05-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Pulliam JRC;van Schalkwyk C;Govender N;von Gottberg A;Cohen C;Groome MJ;Dushoff J;Mlisana K;Moultrie H
通讯作者：
Moultrie H
估计新兴流行病中的个体和家庭繁殖数量。
影响因子：
3.7
作者：
Fraser C
通讯作者：
Fraser C
影响因子：
8.4
作者：
Nishiura, Hiroshi;Linton, Natalie M.;Akhmetzhanov, Andrei R.
通讯作者：
Akhmetzhanov, Andrei R.
DOI：
10.2807/1560-7917.es.2021.26.27.2100570
发表时间：
2021-07
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Ito K;Piantham C;Nishiura H
通讯作者：
Nishiura H