A Novel Computerized Cognitive Stress Test to Detect Mild Cognitive Impairment.
A Novel Computerized Cognitive Stress Test to Detect Mild Cognitive Impairment.
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DOI：
10.14283/jpad.2021.1
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发表时间：
2021
影响因子：
6.4
通讯作者：
Loewenstein, D. A.
中科院分区：
文献类型：
--
作者：
Cid, R. E. Curiel;Crocco, E. A.;Kitaigorodsky, M.;Beaufils, L.;Pena, P. A.;Grau, G.;Visser, U.;Loewenstein, D. A.
关键词：
Loewenstein Acevedo语义干扰和学习量表（LASSI-L）是一种新型的、越来越被广泛使用的工具，作为阿尔茨海默病（AD）前期脑淀粉样蛋白升高和神经退行性变的早期相关指标，它的表现优于广泛使用的认知测量。LASSI-L将健忘轻度认知障碍（aMCI）和高淀粉样蛋白负荷与其他非阿尔茨海默病引起的aMCI区分开来。作者设计并实施了基于网络的简单计算机化仪器lasi - bc，以改善标准化管理，促进评分准确性，实时数据输入，并增加测量的可及性。我们评估了lasi - l简短计算机版的心理测量特性和临床应用，以及它区分认知正常（CN）和遗忘性轻度认知障碍（aMCI）老年人的能力。在使用传统方法进行全面统一的临床和神经心理学评估后，老年人被归类为认知正常或被诊断为aMCI。所有的参与者都进行了lassii - bc测试，这是lassii - l的计算机版本。对每个LASSI-BC子量表进行重测和判别效度评估。lasi - bc量表具有较高的重测信度和判别效度。LASSI-BC是LASSI-L的简单计算机化版本，是检测老年人aMCI的有效和有用的认知工具。
The Loewenstein Acevedo Scales of Semantic Interference and Learning (LASSI-L) is a novel and increasingly employed instrument that has outperformed widely used cognitive measures as an early correlate of elevated brain amyloid and neurodegeneration in prodromal Alzheimer’s Disease (AD). The LASSI-L has distinguished those with amnestic mild cognitive impairment (aMCI) and high amyloid load from aMCI attributable to other non-AD conditions. The authors designed and implemented a web-based brief computerized version of the instrument, the LASSI-BC, to improve standardized administration, facilitate scoring accuracy, real-time data entry, and increase the accessibility of the measure. The psychometric properties and clinical utility of the brief computerized version of the LASSI-L was evaluated, together with its ability to differentiate older adults who are cognitively normal (CN) from those with amnestic Mild Cognitive Impairment (aMCI). After undergoing a comprehensive uniform clinical and neuropsychological evaluation using traditional measures, older adults were classified as cognitively normal or diagnosed with aMCI. All participants were administered the LASSI-BC, a computerized version of the LASSI-L. Test-retest and discriminant validity was assessed for each LASSI-BC subscale. LASSI-BC subscales demonstrated high test-retest reliability, and discriminant validity was attained. The LASSI-BC, a brief computerized version of the LASSI-L is a valid and useful cognitive tool for the detection of aMCI among older adults.
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影响因子：
14
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
MCHUGH, PR