Patient-reported outcomes of topical therapies in actinic keratosis: A systematic review.
Patient-reported outcomes of topical therapies in actinic keratosis: A systematic review.
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光化性角化病局部治疗的患者报告结局：一项系统性综述。
DOI：
10.1111/dth.14833
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发表时间：
2021-03
影响因子：
3.6
通讯作者：
Damiani G
中科院分区：
文献类型：
--
作者：
Grada A;Feldman SR;Bragazzi NL;Damiani G
患者对光化性角化病治疗的看法可能会影响治疗依从性，从而影响治疗结果。我们进行了一项系统的综述，以评估患者对光化性角化病的局部、野定向治疗的看法。进行了文献搜索，确定了14项研究，涉及4433名患者。只有四项研究集中在面部和/或头皮，这是典型的影响患者生活质量的部位。有四项研究是临床试验。一项研究利用了专门为光化性角化病开发的经过验证的患者报告结果(PRO)仪器。总体而言，疗程较短的治疗方案，如吲哚甲丁酸酯凝胶，治疗依从性和患者满意度更好。咪喹莫特在一项研究中改善了生活质量，但在另一项研究中却没有。没有关于外用吡罗昔康的数据。这些发现强调了对光化性角化病进行有效、耐受性好、持续时间短的局部治疗的必要性。
Patients' perspectives on actinic keratosis treatments may have an impact on treatment adherence and, therefore, therapeutic outcomes. We performed a systematic review to assess patients' perspectives of topical, field‐directed treatments for actinic keratoses. A literature search was conducted, and 14 studies were identified encompassing 4433 patients. Only four studies were focused on face and/or scalp, which are the locations that typically impact patients' quality of life. Four studies were clinical trials. One study utilized a validated patient‐reported outcomes (PRO) instrument specifically developed for actinic keratosis. In general, treatment adherence and patient satisfaction were better with shorter‐duration treatment regimens such as ingenol mebutate gel. Imiquimod improved quality of life in one study but not in another. No data was available on topical piroxicam. The findings underscore the need for effective and well‐tolerated, short‐duration topical treatment for actinic keratosis.
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影响因子：
3.6
作者：
Grada A;Feldman SR;Bragazzi NL;Damiani G
通讯作者：
Damiani G
影响因子：
1.7
作者：
Gameiro, Luiz;Tovo, Luis Fernando Requejo;Aprahamian, Ivan
通讯作者：
Aprahamian, Ivan
影响因子：
13.8
作者：
Hanke, C. William;Albrecht, Lorne;Spelman, Lynda
通讯作者：
Spelman, Lynda
影响因子：
2.9
作者：
Norrlid, Hanna;Norlin, Jenny M.;Tennvall, Gunnel Ragnarson
通讯作者：
Tennvall, Gunnel Ragnarson
DOI：
10.2147/ccid.s121323
发表时间：
2017
期刊：
Clinical, cosmetic and investigational dermatology
影响因子：
--
作者：
Khanna R;Bakshi A;Amir Y;Goldenberg G
通讯作者：
Goldenberg G