Serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats.
Serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats.
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DOI：
10.1016/j.pbb.2011.01.024
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发表时间：
2011-05
影响因子：
3.6
通讯作者：
Murphy, Anne Z.
中科院分区：
文献类型：
--
作者：
Normandin, Joseph J.;Murphy, Anne Z.
尽管选择性5-羟色胺再摄取抑制剂(SSRI)被广泛用于治疗焦虑和抑郁，但它们也会产生严重的性功能障碍，包括性高潮/射精延迟。巨细胞旁核(NPGi)是雄性大鼠射精抑制的主要来源，含有5-羟色胺(5-HT)受体。腹外侧导水管周围灰质(VlPAG)为该区域提供5-羟色胺，从而为5-羟色胺能调节nPGi提供解剖学和神经化学基础。我们推测，作用于nPGi的5-羟色胺可能是SSRI抑制啮齿类动物射精的基础。为此，我们制作了5-羟色胺对nPGi(VlPAG)来源的损毁，并检查了性行为。去掉nPGi的5-羟色胺来源会促进生殖器反射，但不会促进性行为的其他方面，这与我们的假设一致。也就是说，与假手术组相比，5-羟色胺损毁导致射精次数显著增加，射精潜伏期显著缩短，而交配潜伏期和射精后间期没有差异。这些结果表明，5-羟色胺能的vlPAG-nPGi通路是抑制射精的重要调节机制，并支持该通路参与SSRI诱导的射精抑制的假说。
While selective serotonin reuptake inhibitors (SSRIs) are widely used to treat anxiety and depression, they also produce profound disruptions of sexual function including delayed orgasm/ejaculation. The nucleus paragigantocellularis (nPGi), a primary source of inhibition of ejaculation in male rats, contains receptors for serotonin (5-HT). The ventrolateral periaqueductal gray (vlPAG) provides serotonin to this region, thus providing an anatomical and neurochemical basis for serotonergic regulation of the nPGi. We hypothesize that 5-HT acting at the nPGi could underlie the SSRI-induced inhibition of ejaculation in rodents. To this end, we produced 5-HT lesions of the source of 5-HT to the nPGi (the vlPAG) and examined sexual behavior. Removing the source of 5-HT to the nPGi facilitated genital reflexes, but not other aspects of sexual behavior, consistent with our hypothesis. Namely, 5-HT lesions produced a significant increase in the mean number of ejaculations and a significant decrease in ejaculation latency as compared to sham lesioned animals, while latency to mating and the post-ejaculatory interval did not differ. These data suggest that the serotonergic vlPAG-nPGi pathway is an important regulatory mechanism for the inhibition of ejaculation in rats, and supports the hypothesis that this circuit contributes to SSRI-induced inhibition of ejaculation.
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影响因子：
4.1
作者：
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