Metabolic syndrome in healthy obese, overweight, and normal weight individuals: the Atherosclerosis Risk in Communities Study.
Metabolic syndrome in healthy obese, overweight, and normal weight individuals: the Atherosclerosis Risk in Communities Study.
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DOI：
10.1002/oby.20248
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发表时间：
2013-01
期刊：
影响因子：
6.9
通讯作者：
Stevens, June
中科院分区：
文献类型：
--
作者：
Bradshaw, Patrick T.;Monda, Keri L.;Stevens, June
最近的兴趣是描述具有健康代谢特征的肥胖个体的子集，但只有两项研究前瞻性地检查了这一组，但不是在种族多样的人群中。我们分析了与代谢综合征（MetSyn）患病率和发病率相关的因素，这些因素在1987-1989年招募的14，663名年龄在45-64岁的非洲裔美国人和白色男性和女性的多中心、社区队列研究中按体重指数（BMI）类别分组。采用Logistic和比例风险回归估计MetSyn患病率的比值比（OR）和发病率的风险比（HR）及其95%置信区间（CI）。在第1次访问时，MetSyn与年龄，女性性别，非洲裔美国人种族呈正相关，与教育呈负相关，在正常体重（NW）受试者中相关性更明显。在访视1时无MetSyn的受试者中，肥胖（OB）受试者发生MetSyn的可能性高于NW [HR（95% CI）：4.53（4.09-5.01）]。有几个因素与NW中的MetSyn事件相关，包括年龄较大[每年：1.05（1.03-1.06）]，女性[与男性：1.29（1.10-1.52）]、重度酒精摄入[与从不：0.75（0.59-0.94）]和体力活动[三分位数3与三分位数1：0.71（0.58-0.86）]，但不包括OB。与OB [1.01（0.85-1.20）]相比，NW [1.61（1.28-2.02）]中的体重增加（>5%）与MetSyn的相关性也更高。我们的结论是，生活方式因素可能发挥更大的作用，在发展中的MetSyn在NW个人相比，OB和代谢健康的肥胖可能不是一个稳定的条件。
There is recent interest in characterizing the subset of obese individuals who have healthy metabolic profiles yet only two studies have examined this group prospectively but not in racially diverse populations. We analyzed factors associated with the prevalence and incidence of metabolic syndrome (MetSyn) among individuals grouped by body mass index (BMI) categories in a multi-center, community-based cohort of 14,663 African-American and white men and women aged 45-64 years at recruitment in 1987-1989, the Atherosclerosis Risk in Communities study. Logistic and proportional hazards regression were utilized to estimate odds ratios (OR) for the prevalence and hazard ratios (HR) for incidence of MetSyn with 95% confidence intervals (CI). At visit 1, MetSyn was positively associated with age, female gender, African-American race, and inversely related to education, associations being more pronounced among normal weight (NW) subjects. Among those without MetSyn at visit 1, obese (OB) subjects were more likely to develop MetSyn compared with NW [HR (95% CI): 4.53 (4.09-5.01)]. Several factors were associated with incident MetSyn among NW, including older age [per year: 1.05 (1.03-1.06)], female gender [vs. male: 1.29 (1.10-1.52)], heavy alcohol intake [vs. never: 0.75 (0.59-0.94)] and physical activity [tertile 3 vs. tertile 1: 0.71 (0.58-0.86)] but not OB. Weight gain (>5%) was also more highly associated with MetSyn in NW [1.61 (1.28-2.02)] compared with OB [1.01 (0.85-1.20)]. We conclude that lifestyle factors may play a stronger role in development of MetSyn in NW individuals compared with OB and that metabolically healthy obesity may not be a stable condition.
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影响因子：
7.2
作者：
Karelis, A;Brochu, M;Rabasa-Lhoret, R
通讯作者：
Rabasa-Lhoret, R
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Omvik, Per
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作者：
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通讯作者：
Bays, Harold E.