EEG microstate analysis in drug-naive patients with panic disorder.
EEG microstate analysis in drug-naive patients with panic disorder.
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DOI：
10.1371/journal.pone.0022912
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Minabe Y
中科院分区：
文献类型：
--
作者：
Kikuchi M;Koenig T;Munesue T;Hanaoka A;Strik W;Dierks T;Koshino Y;Minabe Y
惊恐障碍(PD)患者有一种以恐惧的方式对正常刺激做出反应的偏见。这可能是由于恐惧相关网络在刺激感知之前被预先激活。在EEG的基础上，我们利用短暂稳定的脑状态(微状态)的特征，研究了帕金森病患者和正常对照组在静息状态活动方面的差异。对18例药物未用药患者和18例健康对照的脑电进行了分析。微状态分析显示，一类微状态(映射视野的右-前-左-后方向)在患者中显示出比对照组更长的持续时间和更多的总时间。与对照组相比，患者中观察到的另一种微状态类型(具有对称的前后取向)较少。帕金森病患者和对照组之间选择的微状态类别不同的观察表明，特定的大脑功能在休息状态下已经发生了改变。这种改变的静息状态可能是观察到的恐惧性刺激功能障碍加工的起点。
Patients with panic disorder (PD) have a bias to respond to normal stimuli in a fearful way. This may be due to the preactivation of fear-associated networks prior to stimulus perception. Based on EEG, we investigated the difference between patients with PD and normal controls in resting state activity using features of transiently stable brain states (microstates). EEGs from 18 drug-naive patients and 18 healthy controls were analyzed. Microstate analysis showed that one class of microstates (with a right-anterior to left-posterior orientation of the mapped field) displayed longer durations and covered more of the total time in the patients than controls. Another microstate class (with a symmetric, anterior-posterior orientation) was observed less frequently in the patients compared to controls. The observation that selected microstate classes differ between patients with PD and controls suggests that specific brain functions are altered already during resting condition. The altered resting state may be the starting point of the observed dysfunctional processing of phobic stimuli.
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