Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure.
Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure.
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DOI：
10.3389/fnins.2023.1182635
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发表时间：
2023
影响因子：
4.3
通讯作者：
Mahnke, Amanda H. H.
中科院分区：
文献类型：
--
作者：
Upreti, Deepa;Rouzer, Siara K. K.;Bowring, Abigail;Labbe, Emma;Kumar, Rosaline;Miranda, Rajesh C. C.;Mahnke, Amanda H. H.
成年后接触酒精会导致炎症、营养不良和胃肠道微生物区系改变，这可能会扰乱有效的营养提取。临床和临床前研究已经令人信服地证明，产前酒精暴露(PAE)也会导致持续的炎症和营养缺乏，尽管关于PAE对肠道微生物区系的影响的研究还处于初级阶段。重要的是，其他神经发育障碍，包括自闭症谱系和注意力缺陷/多动障碍，都与肠道微生物区系失调有关。来自成年期酒精暴露和其他神经发育障碍的综合证据支持这样一种假设，即肠道微生物区系失调可能是导致包括神经发育在内的负面发育的一个病因特征，包括PAE的后果，并导致胎儿酒精谱障碍。在这里，我们强调已发表的数据，这些数据支持肠道微生物区系在健康发展中的作用，并探索这些研究的含义，即改变的微生物区系在PAE的终身健康后果中的作用。
Alcohol exposure in adulthood can result in inflammation, malnutrition, and altered gastroenteric microbiota, which may disrupt efficient nutrient extraction. Clinical and preclinical studies have documented convincingly that prenatal alcohol exposure (PAE) also results in persistent inflammation and nutrition deficiencies, though research on the impact of PAE on the enteric microbiota is in its infancy. Importantly, other neurodevelopmental disorders, including autism spectrum and attention deficit/hyperactivity disorders, have been linked to gut microbiota dysbiosis. The combined evidence from alcohol exposure in adulthood and from other neurodevelopmental disorders supports the hypothesis that gut microbiota dysbiosis is likely an etiological feature that contributes to negative developmental, including neurodevelopmental, consequences of PAE and results in fetal alcohol spectrum disorders. Here, we highlight published data that support a role for gut microbiota in healthy development and explore the implication of these studies for the role of altered microbiota in the lifelong health consequences of PAE.
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