Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells.
Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells.
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DOI：
10.1016/j.biomaterials.2011.11.015
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发表时间：
2012-02
期刊：
影响因子：
14
通讯作者：
Lapotko, Dmitri O.
中科院分区：
文献类型：
--
作者：
Lukianova-Hleb, Ekaterina Y.;Belyanin, Andrey;Kashinath, Shruti;Wu, Xiangwei;Lapotko, Dmitri O.
肿瘤化疗具有多药耐药、高非特异性毒性和肿瘤异质性等特点。我们报告了一种等离子体纳米气泡增强内体逃逸（PNBEE）的方法，用于通过癌细胞的单独靶向的金纳米颗粒和封装的药物（Doxil）的自组装来选择性地、快速地和引导性地向细胞内递送药物。与癌细胞中光学产生的Doxil等离子体纳米泡共定位，将药物释放到细胞质中，从而将针对这些耐药细胞的治疗功效提高了31倍，将药物剂量减少了20倍，治疗时间减少了3倍，与标准治疗相比，非特异性毒性增加了10倍。因此，PNBEE机制提供了在异质环境中选择性、安全和有效的细胞内药物递送，为药物治疗开辟了新的机会。
Cancer chemotherapies suffer from multi drug resistance, high non-specific toxicity and heterogeneity of tumors. We report a method of plasmonic nanobubble-enhanced endosomal escape (PNBEE) for the selective, fast and guided intracellular delivery of drugs through a self-assembly by cancer cells of separately targeted gold nanoparticles and encapsulated drug (Doxil). The co-localized with Doxil plasmonic nanobubbles optically generated in cancer cells released the drug into the cytoplasm thus increasing the therapeutic efficacy against these drug-resistant cells by 31-fold, reducing drug dose by 20-fold, the treatment time by 3-fold and the non-specific toxicity by 10-fold compared to standard treatment. Thus the PNBEE mechanism provided selective, safe and efficient intracellular drug delivery in heterogeneous environment opening new opportunities for drug therapies.
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DOI：
10.1016/j.jconrel.2011.02.006
发表时间：
2011-06-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Lukianova-Hleb EY;Samaniego AP;Wen J;Metelitsa LS;Chang CC;Lapotko DO
通讯作者：
Lapotko DO
影响因子：
17.1
作者：
Meng H;Liong M;Xia T;Li Z;Ji Z;Zink JI;Nel AE
通讯作者：
Nel AE
影响因子：
3.1
作者：
Musacchio, Tiziana;Torchilin, Vladimir P.
通讯作者：
Torchilin, Vladimir P.
影响因子：
10.8
作者：
Paasonen, Lauri;Sipila, Tuomas;Yliperttula, Marjo
通讯作者：
Yliperttula, Marjo
影响因子：
10.8
作者：
Anderson, Lindsey J. E.;Hansen, Eric;Lukianova-Hleb, Ekaterina Y.;Hafner, Jason H.;Lapotko, Dmitri O.
通讯作者：
Lapotko, Dmitri O.