Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology.
Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology.
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DOI：
10.1126/scitranslmed.adh9917
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发表时间：
2023-07-26
影响因子：
17.1
通讯作者：
中科院分区：
文献类型：
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作者：
35个国家正在调查病因不明的儿童严重急性肝炎。虽然已经研究了几种潜在的病因，但在这些病例中观察到的肝损伤的明确原因仍有待确定。利用高通量抗体分析技术VirScan，我们检测了在阿拉巴马州儿童医院治疗的9例病因不明的严重急性肝炎患者的抗体谱，并将他们的抗体反应与38名儿童和470名成人对照进行了比较。我们报告了与对照组相比，病例中腺相关依赖副病毒A （AAV-A）的广度增加，详细的腺相关病毒2 （AAV-2）肽反应在9例病例中有7例是保守的，但在儿童和成人对照组中很少观察到。这些发现提示AAV-2可能是病因不明的严重急性肝炎的病原。AAV-2反应性抗体和AAV-2辅助病毒感染的证据与病因不明的儿童严重急性肝炎有关。
Severe acute hepatitis of unknown etiology in children is under investigation in 35 countries. Although several potential etiologic agents have been investigated, a clear cause for the liver damage observed in these cases remains to be identified. Using VirScan, a high throughput antibody profiling technology, we probed the antibody repertoires of nine cases of severe acute hepatitis of unknown etiology treated at Children’s of Alabama and compared their antibody responses to 38 pediatric and 470 adult controls. We report increased adeno-associated dependoparvovirus A (AAV-A) breadth in cases relative to controls and detailed adeno-associated virus 2 (AAV-2) peptide responses that were conserved in 7 of 9 cases but rarely observed in pediatric and adult control. These findings suggest that AAV-2 is a likely etiologic agent of severe acute hepatitis of unknown etiology. AAV-2-reactive antibodies and evidence of AAV-2 helper virus infection are associated with pediatric severe acute hepatitis of unknown etiology.
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影响因子：
14.9
作者：
Goujon M;McWilliam H;Li W;Valentin F;Squizzato S;Paern J;Lopez R
通讯作者：
Lopez R
影响因子：
4.2
作者：
Day JW;Mendell JR;Mercuri E;Finkel RS;Strauss KA;Kleyn A;Tauscher-Wisniewski S;Tukov FF;Reyna SP;Chand DH
通讯作者：
Chand DH
DOI：
10.1126/science.aay6485
发表时间：
2019-11-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Mina MJ;Kula T;Leng Y;Li M;de Vries RD;Knip M;Siljander H;Rewers M;Choy DF;Wilson MS;Larman HB;Nelson AN;Griffin DE;de Swart RL;Elledge SJ
通讯作者：
Elledge SJ
影响因子：
--
作者：
Calcedo, Roberto;Morizono, Hiroki;Wilson, James M.
通讯作者：
Wilson, James M.
影响因子：
33.9
作者：
Kambhampati, Anita K.;Burke, Rachel M.;Tate, Jacqueline E.
通讯作者：
Tate, Jacqueline E.