Association between age, gender, body mass index, and pulmonary function in preoperative patients with lung cancer.
Association between age, gender, body mass index, and pulmonary function in preoperative patients with lung cancer.
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术前肺癌患者年龄、性别、体重指数和肺功能之间的关联。
DOI：
10.1111/crj.13476
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
许多混杂因素，如性别、年龄和体重指数（BMI）会影响肺功能参数，但关于混杂因素差异中小气道功能对肺功能的直接和/或间接影响的数据有限。
本研究旨在利用结构方程模型（SEM）来解释混杂因素（年龄、性别和BMI）对肺癌患者小气道功能与肺功能之间关系的影响。
在一个单一的医疗中心进行了一项横断面观察性研究。对受试者进行了评估；小气道功能通过最大呼气流量25%（MEF25%）和最大呼气流量50%（MEF50%）来确定；肺功能通过用力肺活量（FVC）来确定；肺阻塞通过第一秒用力呼气容积（FEV1）、第一秒用力呼气容积占预计值百分比（FEV1%）以及第一秒用力呼气容积与用力肺活量的比值（FEV1/FVC）来确定；呼气峰流量（PEF）和呼气峰流量占预计值百分比（PEF%）反映了腹肌的力量。通过验证性因子分析对测量模型进行分析。利用结构方程模型分析混杂因素影响的结构模型。
在测量模型中，变量与其所属领域相匹配，年龄和性别与肺阻塞之间的路径为正且具有统计学意义，性别与肌肉力量之间的路径也为正且具有统计学意义。肌肉力量正向且显著地介导了性别与FVC之间的路径。作为调节因素，BMI增强了小气道功能对FVC的影响。
年龄和性别指向肺阻塞，肌肉力量作为性别与肺功能之间的中介是新颖的，并且BMI调整了小气道功能对FVC的影响。
Many confounding factors such as sex, age, and body mass index (BMI) affect pulmonary function parameters, but there are limited data about the direct and/or indirect effects of small airway function on lung function for differences in confounding factors. This study aimed to use structural equation model (SEM) to explain the influence of the confounding factors (age, sex, and BMI) on the relationship between small airway function and lung function in patients with lung cancer. A cross‐sectional observational study was conducted in a single medical center. Subjects were assessed; small airway function was specified by MEF25% and MEF50%; lung function by FVC; pulmonary obstruction by FEV1, FEV1%, and FEV1/FVC; and PEF and PEF% reflected the strength of abdominal muscles. The measurement model was analyzed by confirmatory factor analysis. The SEM was conducted to analyze the structural models of the effects of the confounding factors. In the measurement model, variables were fit to their domains, the path linking age and sex to pulmonary obstruction was positive and statistically significant, and the path linking sex to muscle strength was also positive and statistically significant. Muscle strength positively and significantly mediates the path between sex and FVC. As a moderator, BMI increased the effects of small airway function on FVC. Age and sex were directed to pulmonary obstruction, and muscle strength as a mediator between sex and lung function was novel, and BMI adjusted the effects of small airway function on FVC.
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影响因子：
1.2
作者：
Saito, Hiroshi;Shiraishi, Atsushi;Kawama, Kennosuke
通讯作者：
Kawama, Kennosuke
影响因子：
6.3
作者：
YAMAGUCHI, S;KANO, K;LU, L
通讯作者：
LU, L
影响因子：
4.6
作者：
Do, Jong Geol;Park, Chul-Hyun;Yoon, Kyung Jae
通讯作者：
Yoon, Kyung Jae
影响因子：
1.6
作者：
Li, Yan;Dai, Yong-liang;Guo, You-min
通讯作者：
Guo, You-min
影响因子：
10
作者：
Ekström S;Hallberg J;Kull I;Protudjer JLP;Thunqvist P;Bottai M;Gustafsson PM;Bergström A;Melén E
通讯作者：
Melén E