Near infrared luminescent oxygen nanosensors with nanoparticle matrix tailored sensitivity.
Near infrared luminescent oxygen nanosensors with nanoparticle matrix tailored sensitivity.
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DOI：
10.1021/ac1015358
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发表时间：
2010-10-15
影响因子：
7.4
通讯作者：
Kopelman, Raoul
中科院分区：
文献类型：
--
作者：
Lee, Yong-Eun Koo;Ulbrich, Elyse E.;Kim, Gwangseong;Hah, Hoejin;Strollo, Christen;Fan, Wenzhe;Gurjar, Rajan;Koo, Sang Man;Kopelman, Raoul
开发用于无创测定活细胞和组织中氧水平的传感器对于了解细胞功能、监测癌症等疾病状态以及预测治疗效果至关重要。我们描述了这种由聚丙烯酰胺水凝胶、近红外 (NIR) 发光染料和表面缀合的肿瘤特异性肽制成的无毒、靶向和比例式 30nm 氧纳米传感器。他们能够在正常和缺氧条件下对活癌细胞的氧气水平进行非侵入性实时监测。通过调整纳米基质和指示剂染料之间的相互作用来实现所需的灵敏度、亮度、选择性和稳定性。开发的纳米传感器可能对体内氧气测量有用。
The development of sensors for non-invasive determination of oxygen levels in live cells and tissues is critical for the understanding of cellular functions, as well as for monitoring the status of disease, such as cancer, and for predicting the efficacy of therapy. We describe such non-toxic, targeted and ratiometric 30nm oxygen nanosensors made of polyacrylamide hydrogel, near infrared (NIR) luminescent dyes, and surface-conjugated tumor-specific peptides. They enabled non-invasive real-time monitoring of oxygen levels in live cancer cells under normal and hypoxic conditions. The required sensitivity, brightness, selectivity and stability were achieved by tailoring the interaction between the nanomatrix and indicator dyes. The developed nanosensors may become useful for in vivo oxygen measurements.
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影响因子：
4.2
作者：
Cao, YF;Koo, YEL;Kopelman, R
通讯作者：
Kopelman, R
影响因子：
7.4
作者：
Borisov, Sergey M.;Wolfbeis, Otto S.
通讯作者：
Wolfbeis, Otto S.
影响因子：
2.9
作者：
Dunphy, I;Vinogradov, SA;Wilson, DF
通讯作者：
Wilson, DF
影响因子：
7.4
作者：
Koo, YEL;Cao, YF;Philbert, MA
通讯作者：
Philbert, MA
影响因子：
5.7
作者：
Borisov, Sergey M.;Klimant, Ingo
通讯作者：
Klimant, Ingo