On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms.
On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms.
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DOI：
10.1146/annurev-ecolsys-120213-091705
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发表时间：
2014-11-01
期刊：
影响因子：
--
通讯作者：
Leu JY
中科院分区：
文献类型：
--
作者：
Siegal ML;Leu JY
生物学家早就观察到，生理和发育过程对许多遗传和环境扰动不敏感，或者说是稳健的。缺乏对这种鲁棒性的进化原因和后果的完整理解。最近在揭示特别是环境稳健性所依据的管理机制方面取得了进展。对突变影响的鲁棒性知之甚少，事实上，突变鲁棒性的进化仍然是一个有争议的话题。争论已经扩展到相关的主题，特别是神秘遗传变异的进化相关性。这篇综述的目的是综合目前对稳健性机制的理解，并通过阐明什么是和不知道突变稳健性来切入争议。一些研究混淆了突变稳健性与突变之间的非加性相互作用（上位性）。我们的结论是，一个有利可图的方式是集中调查（和修辞）少突变的鲁棒性和上位性。
Biologists have long observed that physiological and developmental processes are insensitive, or robust, to many genetic and environmental perturbations. A complete understanding of the evolutionary causes and consequences of this robustness is lacking. Recent progress has been made in uncovering the regulatory mechanisms that underlie environmental robustness in particular. Less is known about robustness to the effects of mutations, and indeed the evolution of mutational robustness remains a controversial topic. The controversy has spread to related topics, in particular the evolutionary relevance of cryptic genetic variation. This review aims to synthesize current understanding of robustness mechanisms and to cut through the controversy by shedding light on what is and is not known about mutational robustness. Some studies have confused mutational robustness with non-additive interactions between mutations (epistasis). We conclude that a profitable way forward is to focus investigations (and rhetoric) less on mutational robustness and more on epistasis.
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影响因子：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1006/bbrc.1997.7552
发表时间：
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影响因子：
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