Effects of day-time exposure to different light intensities on light-induced melatonin suppression at night.
Effects of day-time exposure to different light intensities on light-induced melatonin suppression at night.
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DOI：
10.1186/s40101-015-0067-1
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发表时间：
2015-07-04
影响因子：
3.1
通讯作者：
Hatae K
中科院分区：
文献类型：
--
作者：
Kozaki T;Kubokawa A;Taketomi R;Hatae K
众所周知，夜间的强光会抑制褪黑激素的分泌。然而，白天的强光暴露可能会减少夜间光诱导的褪黑素抑制(LIMS)。白天光和夜间光的有效比例尚不清楚；然而，关于准确控制白天和夜间条件的研究还很少。本研究旨在评估不同日间光照强度对LIMS的影响。12名年龄在19岁至23岁之间的男性受试者(平均 ± S.D.，20.8 ± 1.1)知情同意参与本研究。他们在09：00到12：00(白天的光照条件)之间暴露在不同的光照条件(<；10、100、300、900和2700lx)中。然后，他们在01：00至02：30(夜间光线暴露)之间再次暴露在强光(300xlx)下。他们提供了夜间光照前(00：55)和夜间光照后(02：30)的唾液样本。单尾配对t检验发现，在白天昏暗、100和300lx的光照条件下，夜间光照后褪黑素浓度显著降低。在白天900和2700lx的光照条件下，夜间光照前后褪黑激素浓度没有显著差异。目前的研究结果表明，在有一般生活节奏(睡眠/醒来时间表)的个人中，预防由普通夜间光线引起的LIMS所需的光照量。这些发现可能有助于在医院和地下购物中心为人类实施人工光环境。
Bright nocturnal light has been known to suppress melatonin secretion. However, bright light exposure during the day-time might reduce light-induced melatonin suppression (LIMS) at night. The effective proportion of day-time light to night-time light is unclear; however, only a few studies on accurately controlling both day- and night-time conditions have been conducted. This study aims to evaluate the effect of different day-time light intensities on LIMS. Twelve male subjects between the ages of 19 and 23 years (mean ± S.D., 20.8 ± 1.1) gave informed consent to participate in this study. They were exposed to various light conditions (<10, 100, 300, 900 and 2700 lx) between the hours of 09:00 and 12:00 (day-time light conditions). They were then exposed to bright light (300 lx) again between 01:00 and 02:30 (night-time light exposure). They provided saliva samples before (00:55) and after night-time light exposure (02:30). A one-tailed paired t test yielded significant decrements of melatonin concentration after night-time light exposure under day-time dim, 100- and 300-lx light conditions. No significant differences exist in melatonin concentration between pre- and post-night-time light exposure under day-time 900- and 2700-lx light conditions. Present findings suggest the amount of light exposure needed to prevent LIMS caused by ordinary nocturnal light in individuals who have a general life rhythm (sleep/wake schedule). These findings may be useful in implementing artificial light environments for humans in, for example, hospitals and underground shopping malls.
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影响因子：
5.8
作者：
Mishima, K;Okawa, M;Hishikawa, Y
通讯作者：
Hishikawa, Y
影响因子：
2.5
作者：
Figueiro, Mariana G.;Rea, Mark S.;Bullough, John D.
通讯作者：
Bullough, John D.
唾液褪黑激素分泌的数量和时机的个体差异。
影响因子：
3.7
作者：
Burgess, Helen J.;Fogg, Louis F.
通讯作者：
Fogg, Louis F.
DOI：
10.1152/ajpregu.00355.2006
发表时间：
2007-06-01
影响因子：
2.8
作者：
Higuchi, Shigekazu;Motohashi, Yutaka;Maeda, Takafumi
通讯作者：
Maeda, Takafumi
影响因子：
11.2
作者：
Blask, DE;Brainard, GC;Zalatan, F
通讯作者：
Zalatan, F