Cortical activation during delay discounting in abstinent methamphetamine dependent individuals.
Cortical activation during delay discounting in abstinent methamphetamine dependent individuals.
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DOI：
10.1007/s00213-008-1261-1
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发表时间：
2008-12
影响因子：
3.4
通讯作者：
Mitchell, Suzanne H.
中科院分区：
文献类型：
--
作者：
Hoffman, William F.;Schwartz, Daniel L.;Huckans, Marilyn S.;McFarland, Bentson H.;Meiri, Gal;Stevens, Alexander A.;Mitchell, Suzanne H.
在延迟折扣(DD)任务中，甲基安非他明(MA)依赖者更喜欢较小的即时奖励，而不是较大的延迟奖励。人类和动物的数据在DD决策中涉及腹侧(杏仁核、腹侧纹状体、腹外侧额前皮质岛)和背侧(背外侧前额叶皮质、背侧前扣带回皮质和后顶叶皮质)系统。腹侧系统被假设为对奖励的突显和即时性做出反应，而背侧系统被牵连到比较和选择的过程中。我们使用功能磁共振成像技术在19名近期戒毒的MA依赖患者和17名年龄和性别匹配的对照组中探讨了DD的神经相关性。双侧扣带回中部、顶叶后皮质(PPC)和右侧吻侧岛叶的激活程度最高。对照组在双侧楔前核、右侧尾状核、扣带回前皮质(ACC)和背外侧前额叶皮质(DLPFC)激活程度高于MA组。折扣的大小与杏仁核、DLPFC、后扣带皮质和PPC的活动相关。我们的发现与背侧认知系统调节腹侧区域神经反应的模型一致。对MA上瘾的患者，他们强烈喜欢较小的即时奖赏而不是较大的延迟奖赏，他们激活背侧认知控制系统，以克服他们的偏好。在选择延迟奖励的过程中，杏仁核的激活与更大程度的折扣有关，这表明严重折扣MA依赖的人可能比对照组对延迟奖励的负面显著更敏感。
Methamphetamine (MA)-dependent individuals prefer smaller immediate over larger delayed rewards in delay discounting (DD) tasks. Human and animal data implicate ventral (amygdala, ventral striatum, ventrolateral prefrontal cortex insula) and dorsal (dorsolateral prefrontal cortex, dorsal anterior cingulate cortex and posterior parietal cortex) systems in DD decisions. The ventral system is hypothesized to respond to the salience and immediacy of rewards while the dorsal system is implicated in the process of comparison and choice. We used functional Magnetic Resonance Imaging to probe the neural correlates of DD in 19 recently abstinent MA-dependent patients and 17 age- and gender-matched controls. Hard DD choices were associated with greatest activation in bilateral middle cingulate, posterior parietal cortex (PPC), and the right rostral insula. Control subjects showed more activation than MA patients bilaterally in the precuneus and in the right caudate nucleus, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC). Magnitude of discounting was correlated with activity in the amygdala, DLPFC, posterior cingulate cortex and PPC. Our findings were consistent with a model wherein dorsal cognitive systems modulate the neural response of ventral regions. Patients addicted to MA, who strongly prefer smaller immediate over larger delayed rewards, activate the dorsal cognitive control system in order to overcome their preference. Activation of the amygdala during choice of delayed rewards was associated with a greater degree of discounting, suggesting that heavily discounting MA-dependent individuals may be more responsive to the negative salience of delayed rewards than controls.
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影响因子：
2.7
作者：
Johnson, MW;Bickel, WK
通讯作者：
Bickel, WK
影响因子：
3.4
作者：
Mitchell, SH
通讯作者：
Mitchell, SH
影响因子：
5.3
作者：
Boettiger, Charlotte A.;Mitchell, Jennifer M.;Fields, Howard L.
通讯作者：
Fields, Howard L.
影响因子：
--
作者：
Kilts, CD;Schweitzer, JB;Drexler, KPG
通讯作者：
Drexler, KPG
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y