Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure.
Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure.
复制标题
DOI：
10.1038/s41598-018-35129-5
复制
发表时间：
2018-11-09
影响因子：
4.6
通讯作者：
Hampson DR
中科院分区：
文献类型：
--
作者：
Burke AP;Niibori Y;Terayama H;Ito M;Pidgeon C;Arsenault J;Camarero PR;Cummins CL;Mateo R;Sakabe K;Hampson DR
新烟碱类杀虫剂已成为世界上使用最广泛的一类杀虫剂。虽然许多研究已经记录了新烟碱对蜜蜂和其他昆虫的毒性，但在哺乳动物早期发育期间暴露的影响在很大程度上仍未被探索。我们评估了新烟碱类吡虫啉(IMI)对成年雄性和雌性小鼠在宫内和出生后早期暴露的影响。孕鼠从妊娠第4天开始至第21天哺乳结束，灌胃给予IMI0.5 mg/kg/d。对这些年轻的成年后代进行了一系列的生化和行为测试。为了评估重复性，行为分析在三个单独的研究中进行，使用多个暴露的猫砂。暴露于IMI会降低繁殖力，在成年后代中，雄性幼崽的体重会降低，但雌性幼崽的体重没有下降。与接受药物治疗的对照组相比，接受IMI治疗的母亲的后代表现出更低的甘油三酯，更高的运动能力，更强的社交优势，更少的抑郁样行为，以及更少的社交攻击性。在接受治疗的母亲的大脑和肝脏中检测到低水平的IMI，而在一些后代中检测到微量的IMI。我们的结果表明，在发育早期短暂接触新烟碱会导致小鼠行为和脑功能的长期变化。
Neonicotinoids have become the most widely used class of insecticides world-wide. Although numerous studies have documented neonicotinoid toxicity in bees and other insects, the effects of exposure during early development in mammals remain largely unexplored. We assessed the effects of the neonicotinoid imidacloprid (IMI) in adult male and female mice after in utero and early postnatal exposure. Pregnant mice were infused with IMI (0.5 mg/kg/day) from gestational day 4 to the end of nursing at postnatal day 21. The young adult offspring were studied in a series of biochemical and behavioral tests. To assess reproducibility, the behavioral analyses were conducted in three separate studies using multiple exposed litters. Exposure to IMI reduced fecundity, and in adult offspring, decreased body weight in male but not female pups. Offspring from IMI-treated mothers displayed lower triglycerides, elevated motor activity, enhanced social dominance, reduced depressive-like behavior, and a diminution in social aggression compared to vehicle treated controls. Low levels of IMI were detected in the brains and livers of the treated mothers, while trace levels were detected in some offspring. Our results demonstrate that transient exposure to a neonicotinoid over the early developmental period induces long-lasting changes in behavior and brain function in mice.
登录
查看更多内容
DOI：
10.1007/s11356-014-3332-7
发表时间：
2015-01
期刊：
Environmental science and pollution research international
影响因子：
--
作者：
Bonmatin JM;Giorio C;Girolami V;Goulson D;Kreutzweiser DP;Krupke C;Liess M;Long E;Marzaro M;Mitchell EA;Noome DA;Simon-Delso N;Tapparo A
通讯作者：
Tapparo A
影响因子：
10.4
作者：
Cimino AM;Boyles AL;Thayer KA;Perry MJ
通讯作者：
Perry MJ
影响因子：
7.6
作者：
Gholizadeh, Shervin;Arsenault, Jason;Hampson, David R.
通讯作者：
Hampson, David R.
影响因子：
4.7
作者：
Brown, Laurence A.;Ihara, Makoto;Sattelle, David B.
通讯作者：
Sattelle, David B.
影响因子：
2.5
作者：
Déglise, P;Grünewald, B;Gauthier, M
通讯作者：
Gauthier, M