CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer.
CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer.
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CD146是诊断宫颈癌和子宫内膜癌恶性肿瘤的潜在标志物
DOI：
10.3892/ol.2013.1147
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发表时间：
2013-04
期刊：
影响因子：
2.9
通讯作者：
Yan X
中科院分区：
文献类型：
--
作者：
Zhang H;Zhang J;Wang Z;Lu D;Feng J;Yang D;Chen X;Yan X
分化簇146（CD146）是一种内皮细胞粘附分子，其在包括卵巢癌在内的各种类型的恶性肿瘤中过表达。然而，CD146是否在另外两种类型的妇科癌症（宫颈癌和子宫内膜癌）中过表达仍不清楚。在本研究中，我们发现，CD146的表达水平较高的细胞从宫颈癌和子宫内膜癌相比，其相应的正常组织，使用抗CD146小鼠抗体AA4（mAb AA4）和mAb AA4表现出高性能的特异性，灵敏度和阳性预测值在检测这两种类型的癌症。CD146表达与宫颈癌病理类型、子宫内膜癌组织学分级及肌层浸润深度呈正相关。此外，我们证实了CD146存在于宫颈癌和子宫内膜癌的大部分血管中，这表明CD146可能通过血管系统积极参与宫颈癌和子宫内膜癌的转移。因此，这项研究为进一步开发CD146 mAb检测妇科恶性肿瘤类型提供了见解，并意味着抗CD146免疫治疗与其他传统化疗或放疗治疗的联合治疗策略可能是一种有前途的宫颈癌和子宫内膜癌治疗方法。
Cluster of differentiation 146 (CD146) is an endothelial cell adhesion molecule which is overexpressed in various types of malignant cancer, including ovarian cancer. However, whether CD146 is overexpressed in another two types of gynecological cancer, cervical cancer and endometrial cancer, remains unclear. In the present study, we showed that CD146 expression levels were higher in cells from cervical cancer and endometrial cancer compared with their corresponding normal tissues, using anti-CD146 mouse antibody AA4 (mAb AA4) and that mAb AA4 exhibited a high performance for specificity, sensitivity and positive predictive value in the detection of these two types of cancer. CD146 expression was positively and significantly correlated with the pathological subtype of cervical cancer and with the histological grade and depth of myometrial invasion in endometrial cancer. In addition, we confirmed that CD146 is present in the majority of blood vessels in cervical and endometrial cancer, suggesting that CD146 may be actively implicated in the metastasis of cervical and endometrial cancer via the vascular system. Thus, this study provides insights for further development of CD146 mAb in the detection of gynecological malignant cancer types and implies that a combined treatment strategy of anti-CD146 immunotherapy with other traditional chemo- or radiotherapy treatments may be a promising approach against cervical and endometrial cancer.
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影响因子：
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