Periodontal innate immune mechanisms relevant to atherosclerosis and obesity.
Periodontal innate immune mechanisms relevant to atherosclerosis and obesity.
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DOI：
10.1111/j.1600-0757.2010.00358.x
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发表时间：
2010-10
影响因子：
18.6
通讯作者：
Amar S
中科院分区：
文献类型：
--
作者：
Zelkha SA;Freilich RW;Amar S
牙周病具有广泛的临床变异性和严重性。在过去的十年中，研究已经揭示了牙周病的起始感染因子和宿主免疫反应，这两者都被证明可以改变牙周病的进展。库利南等[28]已经表明，高达46%的普通人群携带牙周病的致病微生物，但许多人能够限制牙周病的进展，甚至在感染时清除微生物。总体而言，库利南等人[28]提示牙周病的病因是一个复杂的多因素的，介于免疫反应和环境因素之间，个体对感染因子的免疫反应的特征在很大程度上决定了牙周病的严重程度[119]。Michalowicz等人[82]使用双胞胎研究表明，遗传性似乎对牙周病的临床易感性贡献了大约50%。此外，研究表明先天免疫失调在牙周病的进展中起着关键作用[110]。具体而言，宿主免疫应答在关键模式识别受体的低水平刺激下受到抑制，导致局部免疫应答减弱，从而使牙周病相关细菌（如牙龈卟啉单胞菌）能够逃避宿主免疫系统[86，114]。
Periodontal disease presents with a wide range of clinical variability and severity. Research in the past decade has shed substantial light on both the initiating infectious agents and host immunological responses in periodontal disease, both of which have been shown to modify the progression of periodontal disease. Cullinan et al.[28] have shown that up to 46% of the general population harbor the causative organism (s) of periodontal disease, but many are able to limit the progression of periodontal disease or even clear the organism (s) if infected. Overall, Cullinan et al.[28] suggest a complex multifactorial etiology of periodontal disease between hostimmune'response and environmental factors.The characteristics of an individual's immune response to infectious agents greatly determine the severity of periodontal disease [119]. Michalowicz et al.[82] used a twin study to show that genetic hereditability appears to contribute approximately 50% to the clinical susceptibility of periodontal disease. In addition, studies have suggested dysregulation of innate immunity as playing a key role in progression of periodontal disease [110]. Specifically, the host immune response is suppressed upon low-level stimulation of critical pattern recognition receptors, leading to a muted local immune response, thus enabling periodontal disease-associated bacteria such as Porphyromonas gingivalis to evade host immune system [86,114].
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影响因子：
4.4
作者：
Amar, Salomon;Wu, Shou-chieh;Madan, Monika
通讯作者：
Madan, Monika
DOI：
10.1016/j.jebdp.2008.12.010
发表时间：
2009-03-01
期刊：
The journal of evidence-based dental practice
影响因子：
--
作者：
Dasanayake, Ananda P
通讯作者：
Dasanayake, Ananda P
DOI：
10.1161/01.atv.0000078603.90302.4a
发表时间：
2003-07-01
影响因子：
8.7
作者：
Amar, S;Gokce, N;Vita, JA
通讯作者：
Vita, JA
影响因子：
3
作者：
Cavrini, F;Sambri, V;Cevenini, R
通讯作者：
Cevenini, R
影响因子：
4.8
作者：
Bahekar, Amol Ashok;Singh, Sarabjeet;Arora, Rohit
通讯作者：
Arora, Rohit