Brain function and chromatin plasticity.

Brain function and chromatin plasticity.
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DOI:
10.1038/nature09231
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发表时间:
2010-06-10
期刊:
影响因子:
64.8
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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表观遗传控制的特征,包括对基因表达产生长期、稳定的影响(比初始瞬态信号更持久)的潜力,对于有丝分裂后神经元来说可能具有特殊的重要性,因为这些神经元会发生变化,对其活动和连接产生短期到长期的持续影响。染色质结构的持续变化被认为有助于表观遗传机制。染色质生物学的最新进展为研究神经元长期变化的调控机制提供了新的途径,对大脑功能、行为和疾病的研究具有直接影响。
The characteristics of epigenetic control including the potential for long lasting, stable effects on gene expression that outlive an initial transient signal, could be of singular importance for post-mitotic neurons, which are subject to changes with short to long lasting influence on their activity and connectivity. Persistent changes in chromatin structure are thought to contribute to mechanisms of epigenetic inheritance. Recent advances in chromatin biology offer new avenues to investigate regulatory mechanisms underlying long-lasting changes in neurons, with direct implications for the study of brain function, behavior and diseases.
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