Impaired sustained attention and executive dysfunction: bipolar disorder versus depression-specific markers of affective disorders.
Impaired sustained attention and executive dysfunction: bipolar disorder versus depression-specific markers of affective disorders.
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DOI：
10.1016/j.neuropsychologia.2010.02.015
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发表时间：
2010-05
期刊：
影响因子：
2.6
通讯作者：
Phillips ML
中科院分区：
文献类型：
--
作者：
Maalouf FT;Klein C;Clark L;Sahakian BJ;Labarbara EJ;Versace A;Hassel S;Almeida JR;Phillips ML
目的确定可作为双相情感障碍客观标志物的神经认知指标。方法检测18例双相情感障碍患者(Beuth)、14例抑郁状态(Bdep)、20例单相抑郁(Udep)患者和28例健康对照组(HC)的执行功能、持续注意力和短时记忆作为神经认知域。我们进行了四组比较，随后进行了相关的事后分析。结果SUdep和Bdep，但没有Beuth显示执行功能受损(分别为p=0.045和p=0.046)。Bdep和Beuth，但没有Udep，都表现出持续注意力受损(分别为p=0.001和p=0.045)。这四组人在短期记忆上没有显著差异。持续注意力受损和执行功能障碍与抑郁症的严重程度、病程和发病年龄无关。在Beuth和Beuth中只有少量的神经认知异常与药物有关。结论持续注意障碍似乎是双相情感障碍所特有的，在Beuth和Bdep中都存在，它可能是双相情感障碍的一个客观标志。相比之下，执行功能障碍似乎出现在Udep和Bdep中，可能代表着抑郁症的一个标志。
OBJECTIVETo identify neurocognitive measures that could be used as objective markers of bipolar disorder.METHODSWe examined executive function, sustained attention and short-term memory as neurocognitive domains in 18 participants with bipolar disorder in euthymic state (Beuth), 14 in depressed state (Bdep), 20 with unipolar depression (Udep) and 28 healthy control participants (HC). We conducted four-group comparisons followed by relevant post hoc analyses.RESULTSUdep and Bdep, but not Beuth showed impaired executive function (p=0.045 and p=0.046, respectively). Both Bdep and Beuth, but not Udep, showed impaired sustained attention (p=0.001 and p=0.045, respectively). The four groups did not differ significantly on short-term memory. Impaired sustained attention and executive dysfunction were not associated with depression severity, duration of illness and age of illness onset. Only a small number of abnormal neurocognitive measures were associated with medication in Bdep and Beuth.CONCLUSIONImpaired sustained attention appears specific to bipolar disorder and present in both Beuth and Bdep; it may represent an objective marker of bipolar disorder. Executive dysfunction by contrast, appears to be present in Udep and Bdep and likely represents a marker of depression.
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影响因子：
17.7
作者：
Clark, L;Sarna, A;Goodwin, GM
通讯作者：
Goodwin, GM
DOI：
10.1073/pnas.0337481100
发表时间：
2003-02-04
影响因子：
11.1
作者：
MacQueen, GM;Campbell, S;Young, LT
通讯作者：
Young, LT
影响因子：
3.8
作者：
Bowden, CL
通讯作者：
Bowden, CL
影响因子：
10.6
作者：
Clark, L;Kempton, MJ;Goodwin, GM
通讯作者：
Goodwin, GM
影响因子：
17.7
作者：
Gorwood, Philip;Corruble, Emmanuelle;Goodwin, Guy M.
通讯作者：
Goodwin, Guy M.