Anthropogenic interferences lead to gut microbiome dysbiosis in Asian elephants and may alter adaptation processes to surrounding environments.
Anthropogenic interferences lead to gut microbiome dysbiosis in Asian elephants and may alter adaptation processes to surrounding environments.
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DOI：
10.1038/s41598-020-80537-1
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发表时间：
2021-01-12
影响因子：
4.6
通讯作者：
Katakura K
中科院分区：
文献类型：
--
作者：
Moustafa MAM;Chel HM;Thu MJ;Bawm S;Htun LL;Win MM;Oo ZM;Ohsawa N;Lahdenperä M;Mohamed WMA;Ito K;Nonaka N;Nakao R;Katakura K
人类活动干扰了野生动物，导致许多动物种群的消失。因此，人们一直在努力了解野生动物如何从人为干扰中恢复过来。适应环境和社会变化的一个重要机制是宿主肠道微生物组的波动。在这里，我们给出了亚洲象（n = 30）中由遗传诱导的微生物组改变的全面描述。我们检测到肠道微生物的变化，由于海外易位，圈养和驱虫。我们发现，属于Planococcaceae的微生物在易位后的微生物组变化中的贡献最大，而梭菌科，螺旋体科和拟杆菌属在圈养后受到的影响最大。然而，驱虫显著改变了黄杆菌科，鞘氨醇杆菌科，黄单胞菌科，Weeksellaceae和伯克霍尔德氏菌科的丰度。这些发现可能提供基本的想法，以帮助指导亚洲象肠道微生物组失调的保护策略和益生菌替代疗法。更一般地说，这些结果显示了人类活动在肠道微生物组水平上的严重性，改变了对新环境的适应过程以及随后维持动物正常生理过程的能力。
Human activities interfere with wild animals and lead to the loss of many animal populations. Therefore, efforts have been made to understand how wildlife can rebound from anthropogenic disturbances. An essential mechanism to adapt to environmental and social changes is the fluctuations in the host gut microbiome. Here we give a comprehensive description of anthropogenically induced microbiome alterations in Asian elephants (n = 30). We detected gut microbial changes due to overseas translocation, captivity and deworming. We found that microbes belonging to Planococcaceae had the highest contribution in the microbiome alterations after translocation, while Clostridiaceae, Spirochaetaceae and Bacteroidia were the most affected after captivity. However, deworming significantly changed the abundance of Flavobacteriaceae, Sphingobacteriaceae, Xanthomonadaceae, Weeksellaceae and Burkholderiaceae. These findings may provide fundamental ideas to help guide the preservation tactics and probiotic replacement therapies of a dysbiosed gut microbiome in Asian elephants. More generally, these results show the severity of anthropogenic activities at the level of gut microbiome, altering the adaptation processes to new environments and the subsequent capability to maintain normal physiological processes in animals.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
2.7
作者：
Bansiddhi, Pakkanut;Brown, Janine L.;Nganvongpanit, Korakot
通讯作者：
Nganvongpanit, Korakot
DOI：
10.1073/pnas.1525085113
发表时间：
2016-03-29
影响因子：
11.1
作者：
Gerber, Leah R.
通讯作者：
Gerber, Leah R.
影响因子：
6.4
作者：
Easton, Alice, V;Quinones, Mariam;Nutman, Thomas B.
通讯作者：
Nutman, Thomas B.
影响因子：
4.5
作者：
Allan N;Knotts TA;Pesapane R;Ramsey JJ;Castle S;Clifford D;Foley J
通讯作者：
Foley J