Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans.
Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans.
复制标题
秀丽隐杆线虫雄性长寿的遗传、行为和环境决定因素。
DOI：
10.1093/genetics/154.4.1597
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发表时间：
2000
期刊：
影响因子：
3.3
通讯作者：
Riddle,DL
中科院分区：
文献类型：
--
作者：
Gems,D;Riddle,DL
秀丽隐杆线虫的雄性在单一性别的群体中比雌雄同体的寿命短。我们观察到，成群的年轻雄性形成团块，独居的雄性寿命更长，这表明雄性之间的相互作用缩短了寿命。相比之下，分组或分离的雌雄同体表现出相同的寿命。在一个秀丽隐杆线虫的野生分离株AB2中，有证据表明雄性之间存在交配。9个不协调（unc）突变被用来阻断结块行为。在大多数情况下，这些突变对雌雄同体的寿命几乎没有影响，但许多突变增加了雄性的寿命，甚至超过了独居野生型雄性的寿命。在一个案例中，神经元功能突变体unc-64(e246)，雌雄同体的寿命也增加了60%。unc-4（e120）、unc-13（e51）和unc-32（e189）雄性的寿命比雌雄同体的寿命高出70 ~ 120%。这种差异似乎反映了性别特异性寿命潜力的差异，这种差异揭示了男性行为不利于生存的缺失。男性的长寿似乎不受daf-2的影响，而是受daf-16的影响。在缺乏男女相互作用的情况下，男性寿命的中位数（而不是最大值）是可变的。当死细菌被用作食物时，这种可变性就降低了。对死细菌的维持延长了雄性和雌雄同体的寿命。
Males of the nematode Caenorhabditis elegans are shorter lived than hermaphrodites when maintained in single-sex groups. We observed that groups of young males form clumps and that solitary males live longer, indicating that male-male interactions reduce life span. By contrast, grouped or isolated hermaphrodites exhibited the same longevity. In one wild isolate of C. elegans, AB2, there was evidence of copulation between males. Nine uncoordinated (unc) mutations were used to block clumping behavior. These mutations had little effect on hermaphrodite life span in most cases, yet many increased male longevity even beyond that of solitary wild-type males. In one case, the neuronal function mutant unc-64(e246), hermaphrodite life span was also increased by up to 60%. The longevity of unc-4(e120), unc-13(e51), and unc-32(e189) males exceeded that of hermaphrodites by 70–120%. This difference appears to reflect a difference in sex-specific life span potential revealed in the absence of male behavior that is detrimental to survival. The greater longevity of males appears not to be affected by daf-2, but is influenced by daf-16. In the absence of male-male interactions, median (but not maximum) male life span was variable. This variability was reduced when dead bacteria were used as food. Maintenance on dead bacteria extended both male and hermaphrodite longevity.
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DOI：
10.1101/087969532.33.791
发表时间：
1997
期刊：
--
影响因子：
--
作者：
C. Kenyon
通讯作者：
C. Kenyon
秀丽隐杆线虫的寿命和其他生活史特征不存在强杂种优势。
影响因子：
3.3
作者：
Johnson,TE;Hutchinson,EW
通讯作者：
Hutchinson,EW
DOI：
10.1073/pnas.79.21.6603
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
JOHNSON, TE;WOOD, WB
通讯作者：
WOOD, WB
影响因子：
3.3
作者：
D. Friedman;T. Johnson
通讯作者：
D. Friedman;T. Johnson
影响因子：
56.9
作者：
JOHNSON, TE
通讯作者：
JOHNSON, TE