Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.
Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.
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DOI：
10.1002/hbm.23336
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发表时间：
2016-12
影响因子：
4.8
通讯作者：
Hong, L. Elliot
中科院分区：
文献类型：
--
作者：
Kochunov, Peter;Ganjgahi, Habib;Winkler, Anderson;Kelly, Sinead;Shukla, Dinesh K.;Du, Xiaoming;Jahanshad, Neda;Rowland, Laura;Sampath, Hemalatha;Patel, Binish;O'Donnell, Patricio;Xie, Zhiyong;Paciga, Sara A.;Schubert, Christian R.;Chen, Jian;Zhang, Guohao;Thompson, Paul M.;Nichols, Thomas E.;Hong, L. Elliot
改变的大脑连接与精神分裂症的发展和临床负担有关。相对于匹配的对照组，精神分裂症患者显示（1）使用扩散张量成像（DTI）各向异性分数（FA）评估的大脑白色物质（WM）完整性的整体和区域降低，以及（2）FA值的加速年龄相关性下降。在迄今为止最大的大型分析中，我们测试了WM束发展轨迹的差异是否会影响FA的患者对照差异。我们还评估了特定的大片是否随着年龄的增长而恶化。三个队列的精神分裂症患者（总n=177）和对照组（总n=249;年龄=18-61岁）确定与三个3 T西门子MRI扫描仪。使用ENIGMA-DTI协议提取全脑和局部FA值。使用大型和荟萃分析评估统计学，以检测诊断和年龄与诊断相互作用的影响。在全脑平均FA的大分析中，与对照组相比，精神分裂症患者的FA较低（p=10−11），FA的年龄相关下降较快（p=0.02）。区域特异性异时性测量，即，青春期成熟和衰老的异常率解释了患者诊断和年龄与诊断相互作用的区域方差效应的约50%。结果的交互式3D可视化可在www.enigma-viewer.org上获得。在生命后期成熟的WM束似乎对精神分裂症的病理生理学更敏感，并且更容易发生与年龄相关的FA值更快下降。
Altered brain connectivity is implicated in the development and clinical burden of schizophrenia. Relative to matched controls, schizophrenia patients show (1) a global and regional reduction in the integrity of the brain’s white matter (WM), assessed using diffusion tensor imaging (DTI) fractional anisotropy (FA), and (2) accelerated age-related decline in FA values. In the largest mega-analysis to date, we tested if differences in the trajectories of WM tract development influenced patient-control differences in FA. We also assessed if specific tracts showed exacerbated decline with aging. Three cohorts of schizophrenia patients (total n=177) and controls (total n=249; age=18–61 years) were ascertained with three 3T Siemens MRI scanners. Whole-brain and regional FA values were extracted using ENIGMA-DTI protocols. Statistics were evaluated using mega- and meta-analyses to detect effects of diagnosis and age-by-diagnosis interactions. In mega-analysis of whole-brain averaged FA, schizophrenia patients had lower FA (p=10−11) and faster age-related decline in FA (p=0.02) compared to controls. Tract-specific heterochronicity measures, i.e., abnormal rates of adolescent maturation and aging explained ~50% of the regional variance effects of diagnosis and age-by-diagnosis interaction in patients. Interactive, 3D visualization of the results is available at www.enigma-viewer.org. WM tracts that mature later in life appeared more sensitive to the pathophysiology of schizophrenia and were more susceptible to faster age-related decline in FA values.
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影响因子：
1.7
作者：
Agartz, I;Andersson, JLR;Skare, S
通讯作者：
Skare, S
影响因子：
5.7
作者：
Fjell, Anders M.;Walhovd, Kristine B.;Dale, Anders M.
通讯作者：
Dale, Anders M.
影响因子：
2.9
作者：
Hasan KM;Iftikhar A;Kamali A;Kramer LA;Ashtari M;Cirino PT;Papanicolaou AC;Fletcher JM;Ewing-Cobbs L
通讯作者：
Ewing-Cobbs L
影响因子：
4.2
作者：
Bartzokis, George;Lu, Po H.;Tingus, Kathleen;Mendez, Mario F.;Richard, Aurore;Peters, Douglas G.;Oluwadara, Bolanle;Barrall, Katherine A.;Finn, J. Paul;Villablanca, Pablo;Thompson, Paul M.;Mintz, Jim
通讯作者：
Mintz, Jim
影响因子：
3.5
作者：
Alba-Ferrara LM;de Erausquin GA
通讯作者：
de Erausquin GA