Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions.
Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions.
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DOI：
10.1186/s13567-018-0561-7
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发表时间：
2018-07-31
影响因子：
4.4
通讯作者：
Van Immerseel F
中科院分区：
文献类型：
--
作者：
Hoelzer K;Bielke L;Blake DP;Cox E;Cutting SM;Devriendt B;Erlacher-Vindel E;Goossens E;Karaca K;Lemiere S;Metzner M;Raicek M;Collell Suriñach M;Wong NM;Gay C;Van Immerseel F
疫苗和其他替代产品是畜牧业未来成功的关键，因为它们可以通过预防和控制动物种群中的传染病来帮助最大限度地减少对抗生素的需求。为了评估与抗生素替代品有关的科学进展，并提供支持其发展的可行战略，美国农业部在世界动物卫生组织的支持下，组织了第二届抗生素替代品国际研讨会。它侧重于六个关键领域：疫苗;微生物衍生产品;非营养性植物化学品;免疫相关产品;化学品，酶和创新药物;以及能够开发和许可抗生素替代品的监管途径。本文是两部分系列的第二部分，重点介绍了开发疫苗作为食品生产动物抗生素替代品的新方法和潜在解决方案;在本系列的第一部分中讨论了开发此类疫苗的机遇，挑战和需求。正如本文第1部分所讨论的，目前许多疫苗在一个或多个方面都达不到理想的疫苗。克服这些限制的有希望的突破包括新的生物技术技术、新的口服疫苗方法、新的佐剂、基于细菌孢子的新的递送策略和活重组载体;它们还包括新的卵内疫苗接种策略和同时保护免受多种病原体的策略。然而，将这项研究转化为有效减少抗生素需求的商业疫苗将需要利益攸关方之间的密切合作，例如通过公私伙伴关系。需要有针对性的研发投资和所有受影响者的共同努力，以实现疫苗在改善动物健康、保障农业生产力、减少抗生素消费和由此产生的耐药性风险方面的潜力。
Vaccines and other alternative products are central to the future success of animal agriculture because they can help minimize the need for antibiotics by preventing and controlling infectious diseases in animal populations. To assess scientific advancements related to alternatives to antibiotics and provide actionable strategies to support their development, the United States Department of Agriculture, with support from the World Organisation for Animal Health, organized the second International Symposium on Alternatives to Antibiotics. It focused on six key areas: vaccines; microbial-derived products; non-nutritive phytochemicals; immune-related products; chemicals, enzymes, and innovative drugs; and regulatory pathways to enable the development and licensure of alternatives to antibiotics. This article, the second part in a two-part series, highlights new approaches and potential solutions for the development of vaccines as alternatives to antibiotics in food producing animals; opportunities, challenges and needs for the development of such vaccines are discussed in the first part of this series. As discussed in part 1 of this manuscript, many current vaccines fall short of ideal vaccines in one or more respects. Promising breakthroughs to overcome these limitations include new biotechnology techniques, new oral vaccine approaches, novel adjuvants, new delivery strategies based on bacterial spores, and live recombinant vectors; they also include new vaccination strategies in-ovo, and strategies that simultaneously protect against multiple pathogens. However, translating this research into commercial vaccines that effectively reduce the need for antibiotics will require close collaboration among stakeholders, for instance through public–private partnerships. Targeted research and development investments and concerted efforts by all affected are needed to realize the potential of vaccines to improve animal health, safeguard agricultural productivity, and reduce antibiotic consumption and resulting resistance risks.
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DOI：
10.1016/j.ijpddr.2014.10.002
发表时间：
2014-12
影响因子：
4
作者：
Chapman, H. David;Jeffers, Thomas K.
通讯作者：
Jeffers, Thomas K.
影响因子：
4
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Clark EL;Macdonald SE;Thenmozhi V;Kundu K;Garg R;Kumar S;Ayoade S;Fornace KM;Jatau ID;Moftah A;Nolan MJ;Sudhakar NR;Adebambo AO;Lawal IA;Álvarez Zapata R;Awuni JA;Chapman HD;Karimuribo E;Mugasa CM;Namangala B;Rushton J;Suo X;Thangaraj K;Srinivasa Rao AS;Tewari AK;Banerjee PS;Dhinakar Raj G;Raman M;Tomley FM;Blake DP
通讯作者：
Blake DP
影响因子：
3.1
作者：
Clark, MA;Hirst, BH;Jepson, MA
通讯作者：
Jepson, MA
DOI：
10.1073/pnas.1506468112
发表时间：
2015-09-22
影响因子：
11.1
作者：
Blake, Damer P.;Clark, Emily L.;Tomley, Fiona M.
通讯作者：
Tomley, Fiona M.
影响因子：
5.5
作者：
Brandtzaeg, Per
通讯作者：
Brandtzaeg, Per