Wearable Contact Lens Biosensors for Continuous Glucose Monitoring Using Smartphones.
Wearable Contact Lens Biosensors for Continuous Glucose Monitoring Using Smartphones.
复制标题
DOI：
10.1021/acsnano.8b00829
复制
发表时间：
2018-06-26
期刊：
影响因子：
17.1
通讯作者：
Butt H
中科院分区：
文献类型：
--
作者：
Elsherif M;Hassan MU;Yetisen AK;Butt H
低成本、坚固和可重复使用的连续血糖监测系统可以在护理地点提供定量测量，这是一个尚未满足的医疗需求。光学葡萄糖传感器需要复杂和耗时的制造过程，其读数不适用于定量分析。在这里，一种可穿戴的隐形眼镜光学传感器被创造出来，用于在生理条件下连续定量血糖，简化了制造过程，并促进了智能手机的读数。在苯基硼酸功能化的葡萄糖选择性水凝胶薄膜上印刷了周期为1.6μm的光子微结构。当与葡萄糖结合时，微结构体积膨胀，这调节了周期常数。由此产生的布拉格衍射的变化调制了零级和一级光斑之间的空间。在0-50 mM范围内，周期常数与葡萄糖浓度之间存在相关性。传感器的灵敏度为12 nm mm-1，饱和响应时间小于30min。该传感器与商用隐形眼镜集成在一起，利用智能手机摄像头读数进行连续血糖监测。通过智能手机应用程序测量了一级衍射的反射功率，并将其与葡萄糖浓度进行了关联。在连续监测模式下，响应时间为3 S，饱和时间为4分钟。葡萄糖敏感的光子微结构可能在家庭环境中的护理点连续监测设备和诊断方面有应用。
Low-cost, robust, and reusable continuous glucose monitoring systems that can provide quantitative measurements at point-of-care settings is an unmet medical need. Optical glucose sensors require complex and time-consuming fabrication processes, and their readouts are not practical for quantitative analyses. Here, a wearable contact lens optical sensor was created for the continuous quantification of glucose at physiological conditions, simplifying the fabrication process and facilitating smartphone readouts. A photonic microstructure having a periodicity of 1.6 μm was printed on a glucose-selective hydrogel film functionalized with phenylboronic acid. Upon binding with glucose, the microstructure volume swelled, which modulated the periodicity constant. The resulting change in the Bragg diffraction modulated the space between zero- and first-order spots. A correlation was established between the periodicity constant and glucose concentration within 0–50 mM. The sensitivity of the sensor was 12 nm mM–1, and the saturation response time was less than 30 min. The sensor was integrated with commercial contact lenses and utilized for continuous glucose monitoring using smartphone camera readouts. The reflected power of the first-order diffraction was measured via a smartphone application and correlated to the glucose concentrations. A short response time of 3 s and a saturation time of 4 min was achieved in the continuous monitoring mode. Glucose-sensitive photonic microstructures may have applications in point-of-care continuous monitoring devices and diagnostics at home settings.
登录
查看更多内容
影响因子：
62.1
作者：
Nichols, Scott P.;Koh, Ahyeon;Storm, Wesley L.;Shin, Jae Ho;Schoenfisch, Mark H.
通讯作者：
Schoenfisch, Mark H.
影响因子：
7.4
作者：
Alexeev, VL;Sharma, AC;Asher, SA
通讯作者：
Asher, SA
影响因子：
6.6
作者：
ul Hasan, Kamran;Asif, Muhammad H.;Stralfors, Peter
通讯作者：
Stralfors, Peter
影响因子：
12.6
作者：
Kabilan, S;Marshall, AJ;Lowe, CR
通讯作者：
Lowe, CR
影响因子：
6.2
作者：
Matsumoto, A;Ikeda, S;Kataoka, K
通讯作者：
Kataoka, K