The effects of systemic cyclosporine in acute Stevens-Johnson syndrome/toxic epidermal necrolysis on ocular disease.
The effects of systemic cyclosporine in acute Stevens-Johnson syndrome/toxic epidermal necrolysis on ocular disease.
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DOI：
10.1016/j.jtos.2020.05.003
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Saeed HN
中科院分区：
文献类型：
--
作者：
Hall LN;Shanbhag SS;Rashad R;Chodosh J;Saeed HN
评价全身性环孢素A（CsA）治疗Stevens-Johnson综合征（SJS）和中毒性表皮坏死松解症（TEN）患者眼部疾病的疗效。在这项单中心回顾性比较队列研究中，将诊断为SJS/TEN且至少随访3个月的患者分为两组：接受全身性CsA治疗的患者和未接受全身性CsA治疗的患者。比较两组患者末次随访时的最佳矫正视力（BCVA）和慢性眼表并发症评分（COCS）。患者的中位年龄和随访时间分别为29岁（范围：1.5 - 71岁）和16.8个月（范围：3.67 - 91.58个月）。接受系统性CsA的患者与未接受系统性CsA的患者相比，BCVA、COCS、睑板腺功能障碍、角膜缘干细胞缺乏以及粘膜移植和巩膜晶状体的需要没有显著差异。在这个SJS/TEN患者的小队列中，我们可以确定使用全身性CsA作为初始治疗的组成部分与慢性眼部并发症之间没有关联。
To evaluate the effect of systemic cyclosporine (CsA) on ocular disease in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients. In this retrospective, comparative cohort study at a single center, patients with a diagnosis of SJS/TEN and with at least 3 months of follow up were divided into two groups: those who received systemic CsA and those who did not receive systemic CsA. Best-corrected visual acuity (BCVA) and chronic ocular surface complications score (COCS) at final follow-up were compared between the two groups. The median age and follow-up period of patients was 29 years (range, 1.5 to 71 years) and 16.8 months (range, 3.67 to 91.58 months), respectively. BCVA, COCS, meibomian gland dysfunction, limbal stem cell deficiency, and the need for mucous membrane grafting and scleral lenses were not significantly different between patients who received systemic CsA as compared to patients who did not receive systemic CsA. In this small cohort of patients with SJS/TEN, we could identify no association between the use of systemic CsA as a component of their initial therapy and chronic ocular complications.
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DOI：
10.1097/01.bcr.0000150215.78220.79
发表时间：
2005-01-01
期刊：
JOURNAL OF BURN CARE & REHABILITATION
影响因子：
--
作者：
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通讯作者：
Cartotto, R