Validation of the memorial Sloan-Kettering Cancer Center nomogram to predict disease-specific survival after R0 resection in a Chinese gastric cancer population.
Validation of the memorial Sloan-Kettering Cancer Center nomogram to predict disease-specific survival after R0 resection in a Chinese gastric cancer population.
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DOI：
10.1371/journal.pone.0076041
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Su X
中科院分区：
文献类型：
--
作者：
Chen D;Jiang B;Xing J;Liu M;Cui M;Liu Y;Wang Z;Chen L;Yang H;Zhang C;Yao Z;Zhang N;Ji J;Qu H;Su X
预测单个胃癌患者R0切除后的疾病特异性生存(DSS)仍然是临床关注的问题。鉴于中国胃癌的临床病理特征与西方国家有很大差异，本研究旨在评估纪念斯隆-凯特琳癌症中心的诺模图在中国队列中预测胃癌患者发生DSS的概率。对北京大学肿瘤医院和研究所1998~2007年979例胃癌根治术患者的临床资料进行了回顾性分析，并进行了外部验证。使用协调性指数(C指数)和校准图来评估MSKCC诺模图在我们人群中的表现。在中国队列中，MSKCC预测诺模图的C指数为0.74，相比之下，美国癌症联合委员会分期系统(P<；0.0001)的C指数为0.69。提示MSKCC诺模图对中国人群的预后预测价值优于AJCC分期系统。校正曲线图显示，中国患者的实际生存与MSKCC非曲线图预测的生存概率密切相关。此外，MSKCC诺模图预测表明，中国患者IIA/IIB/IIIA/IIIB期患者的生存期具有异质性。在这项研究中，我们外部验证了MSKCC诺模图，用于预测中国人胃癌R0切除后5年和9年DSS的可能性。MSKCC诺模图表现良好，具有良好的区分性和校准性。MSKCC诺模图改善了对生存的个体化预测，并可能帮助中国临床医生和患者进行个人随访计划，并就各种治疗方案做出决策。
Prediction of disease-specific survival (DSS) for individual patient with gastric cancer after R0 resection remains a clinical concern. Since the clinicopathologic characteristics of gastric cancer vary widely between China and western countries, this study is to evaluate a nomogram from Memorial Sloan-Kettering Cancer Center (MSKCC) for predicting the probability of DSS in patients with gastric cancer from a Chinese cohort. From 1998 to 2007, clinical data of 979 patients with gastric cancer who underwent R0 resection were retrospectively collected from Peking University Cancer Hospital & Institute and used for external validation. The performance of the MSKCC nomogram in our population was assessed using concordance index (C-index) and calibration plot. The C-index for the MSKCC predictive nomogram was 0.74 in the Chinese cohort, compared with 0.69 for American Joint Committee on Cancer (AJCC) staging system (P<0.0001). This suggests that the discriminating value of MSKCC nomogram is superior to AJCC staging system for prognostic prediction in the Chinese population. Calibration plots showed that the actual survival of Chinese patients corresponded closely to the MSKCC nonogram-predicted survival probabilities. Moreover, MSKCC nomogram predictions demonstrated the heterogeneity of survival in stage IIA/IIB/IIIA/IIIB disease of the Chinese patients. In this study, we externally validated MSKCC nomogram for predicting the probability of 5- and 9-year DSS after R0 resection for gastric cancer in a Chinese population. The MSKCC nomogram performed well with good discrimination and calibration. The MSKCC nomogram improved individualized predictions of survival, and may assist Chinese clinicians and patients in individual follow-up scheduling, and decision making with regard to various treatment options.
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影响因子：
2.5
作者：
Strong VE;Song KY;Park CH;Jacks LM;Gonen M;Shah MA;Coit DG;Brennan MF
通讯作者：
Brennan MF
影响因子：
--
作者：
Amedei A;Benagiano M;della Bella C;Niccolai E;D'Elios MM
通讯作者：
D'Elios MM
影响因子：
7.4
作者：
Song, Kyo Young;Park, Yong Gyu;Park, Cho Hyun
通讯作者：
Park, Cho Hyun
影响因子：
3.7
作者：
Dikken JL;Baser RE;Gonen M;Kattan MW;Shah MA;Verheij M;van de Velde CJ;Brennan MF;Coit DG
通讯作者：
Coit DG
影响因子：
2.3
作者：
Koc, Mahmut;Dizen, Hayrettin;Tez, Mesut
通讯作者：
Tez, Mesut