Assessing Higher-Order Visual Processing in Cerebral Visual Impairment Using Naturalistic Virtual-Reality-Based Visual Search Tasks.
Assessing Higher-Order Visual Processing in Cerebral Visual Impairment Using Naturalistic Virtual-Reality-Based Visual Search Tasks.
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DOI：
10.3390/children9081114
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发表时间：
2022-07-26
期刊：
影响因子：
2.4
通讯作者：
Merabet, Lotfi B.
中科院分区：
文献类型：
--
作者：
Manley, Claire E.;Bennett, Christopher R.;Merabet, Lotfi B.
关键词：
脑视觉障碍(CVI)是一种与中枢视觉通路发育不良有关的脑部疾病。患有CVI的人经常报告在日常视觉搜索任务中遇到困难，例如在混乱和拥挤的场景中找到喜欢的玩具或熟悉的人。我们开发了两种新的基于虚拟现实(VR)的视觉搜索任务，并结合眼动跟踪来客观评估CVI中的高阶处理能力。第一个(虚拟玩具盒)模拟静态对象搜索，而第二个(虚拟走廊)表示动态人类搜索任务。参与者被指示寻找预先选择的目标，而任务需求则根据周围分心物的存在进行操纵。我们发现，CVI参与者(与年龄匹配的对照组相比)在两个任务和所有凝视指标上都显示出总体上的视觉搜索障碍。此外，随着任务需求的增加，CVI参与者表现出表现恶化的趋势。最后，视力正常/接近正常的CVI参与者的搜索能力也受到了损害，这表明仅有刺激能见度降低并不能解释这些观察结果。这一新的方法可能在帮助评估与CVI中观察到的功能性视觉加工困难相关的环境因素方面具有重要的临床实用价值。
Cerebral visual impairment (CVI) is a brain-based disorder associated with the maldevelopment of central visual pathways. Individuals with CVI often report difficulties with daily visual search tasks such as finding a favorite toy or familiar person in cluttered and crowded scenes. We developed two novel virtual reality (VR)-based visual search tasks combined with eye tracking to objectively assess higher order processing abilities in CVI. The first (virtual toybox) simulates a static object search, while the second (virtual hallway) represents a dynamic human search task. Participants were instructed to search for a preselected target while task demand was manipulated with respect to the presence of surrounding distractors. We found that CVI participants (when compared to age-matched controls) showed an overall impairment with visual search on both tasks and with respect to all gaze metrics. Furthermore, CVI participants showed a trend of worsening performance with increasing task demand. Finally, search performance was also impaired in CVI participants with normal/near normal visual acuity, suggesting that reduced stimulus visibility alone does not account for these observations. This novel approach may have important clinical utility in helping to assess environmental factors related to functional visual processing difficulties observed in CVI.
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影响因子：
1.8
作者：
Bennett CR;Bex PJ;Merabet LB
通讯作者：
Merabet LB
具有脑视觉障碍和良好视力的儿童的运动处理缺陷。
影响因子：
4.4
作者：
Chandna A;Nichiporuk N;Nicholas S;Kumar R;Norcia AM
通讯作者：
Norcia AM
影响因子：
1.8
作者：
Eckstein, Miguel P.
通讯作者：
Eckstein, Miguel P.
DOI：
10.1073/pnas.88.5.1621
发表时间：
1991-03-01
影响因子：
11.1
作者：
HAXBY, JV;GRADY, CL;RAPOPORT, SI
通讯作者：
RAPOPORT, SI
影响因子：
1.9
作者：
Fazzi, Elisa;Signorini, Sabrina Giovanna;Bianchi, Paolo Emilio
通讯作者：
Bianchi, Paolo Emilio