Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndrome.
Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndrome.
复制标题
肥胖的青春期女孩患有多囊卵巢综合征的睡眠和心脏代谢功能。
DOI：
10.1016/j.sleep.2012.07.002
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发表时间：
2012-12
期刊：
影响因子：
4.8
通讯作者：
Arens, Raanan
中科院分区：
文献类型：
--
作者：
Nandalike, Kiran;Agarwal, Chhavi;Strauss, Temima;Coupey, Susan M.;Isasi, Carmen R.;Sin, Sanghun;Arens, Raanan
关键词：
目的：比较青春期多囊卵巢综合征(PCOS)女孩和匹配的男女对照的多导睡眠图表现和心脏代谢功能。回顾三级护理中心28例多囊卵巢综合征女孩(年龄：16.8±1.9岁，BMI Z评分2.4±0.4)、对照组女性28例(年龄：17.1±1.8，BMI Z评分2.4±0.3)和对照组男性28例(年龄：16.6±1.6，BMI Z评分2.5±0.5)的电子病历。阻塞性睡眠呼吸暂停(OSA)在患有多囊卵巢综合征的女孩中的患病率高于对照组女性(16/28(57%)比4/28(14.3%)，p<；0.01)，但与对照组男性(16/28(57%)比21/28(75%)，p=0.4)相似。患有多囊卵巢综合征的女孩的胰岛素抵抗发生率显著高于对照组女性(20/28(71.4%)比9/22(41.0%)(p=0.04)和对照组8/23(34.8%)(p=0.01)。在患有多囊卵巢综合征的女孩中，OSA患者的代谢综合征比例(9/16(56.3%)比1/12(8.3%)P=0.03)，胰岛素抵抗(13/16(81.3%)比5/12(41.6%)，P=0.03)，白天收缩压升高(128.4±12.8比115.6±11.4，p<；低密度脂蛋白(38.6±8.7vs.49±10.9，p=0.01)，升高甘油三酯(149.7±87.7vs.93.3±25.8，p=0.03)。我们报告了一组患有多囊卵巢综合征的肥胖女孩与没有多囊卵巢综合征的体重指数匹配的对照女孩相比，有睡眠相关主诉的肥胖女孩OSA和代谢功能障碍的患病率更高。我们还报告了患有PCOS和OSA的女孩比没有OSA的PCOS女孩心脏代谢功能障碍的患病率更高。
To compare the polysomnography findings and cardiometabolic function among adolescent girls with PCOS and matched female and male controls. Retrospective chart review of electronic medical records of 28 girls with PCOS (age: 16.8±1.9 yrs, BMI Z-score 2.4±0.4), 28 control females (age: 17.1±1.8, BMI Z-score 2.4±0.3) and 28 control males (age: 16.6±1.6, BMI Z-score 2.5±0.5) in a tertiary care center. The prevalence of obstructive sleep apnea (OSA) was higher in girls with PCOS compared to control females (16/28 (57%) vs. 4/28(14.3%), p<0.01), however, was comparable to that of the control males (16/28(57%) vs. 21/28(75%), p=0.4). Girls with PCOS had a significantly higher prevalence of insulin resistance compared to control females and control males (20/28 (71.4%) vs. 9/22 (41.0%) (p=0.04) vs. 8/23 (34.8%) (p=0.01). Among girls with PCOS, those with OSA had significantly higher proportions of metabolic syndrome (9/16 (56.3% ) vs. 1/12 (8.3%) p=0.03), higher insulin resistance (13/16 (81.3%) vs. 5/12 (41.6%), p=0.03), elevated daytime systolic blood pressure (128.4±12.8 vs. 115.6±11.4, p<0.01), lower HDL (38.6±8.7 vs. 49±10.9, p=0.01) and elevated triglycerides (149.7±87.7 vs. 93.3±25.8, p=0.03) compared to those without OSA. We report a higher prevalence of OSA and metabolic dysfunction in a selected group of obese girls with PCOS referred with sleep related complaints compared to BMI matched control girls without PCOS. We also report higher prevalence of cardiometabolic dysfunction in girls with PCOS and OSA compared to girls with PCOS without OSA.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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