Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index.
Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index.
复制标题
冷冻胚胎移植和孕激素促卵巢刺激对高体重指数女性体外受精结果的影响
DOI：
10.1038/s41598-017-07773-w
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发表时间：
2017-08-07
影响因子：
4.6
通讯作者：
Kuang Y
中科院分区：
文献类型：
--
作者：
Wang L;Yin M;Liu Y;Chen Q;Wang Y;Ai A;Fu Y;Yan Z;Jin W;Long H;Lyu Q;Kuang Y
在接受体外受精的妇女中，当使用传统的卵巢刺激方案结合新鲜胚胎移植时，高BMI会对妊娠结局产生负面影响。因此，在肥胖盛行的情况下，为这些高BMI女性找到合适的治疗方法变得更加重要和紧迫。将4457例妇女分为正常体重指数组(18.5 kg/m2~24.9 kg/m2)和高体重指数组(≥25 kg/m2)，进行了4611个周期的体外受精-冷冻胚胎移植。我们发现，高BMI组原本卵母细胞性能较差，但FET后获得的妊娠结局与正常BMI组相似。结果显示，在高体重指数组中，hMG + (4或10 mg/d)组的妊娠结局明显好于传统的短促排卵组，二元Logistic回归分析显示hMG Mpa(10 mgMpa/d)组的妊娠结局明显好于hMG Mpa(4 mgMpa/d)组。这些结果表明，PPoS-hMG + -Mpa(10 mg/d)联合FET可能是一种新的潜在的治疗方案。
Among women undergoing IVF, high BMI negatively affects pregnancy outcomes when using the conventional ovary stimulating protocols combined with fresh embryo transfer. Therefore, finding a proper treatment for these high BMI women is more important and urgent when obesity is prevalent. In our study, we reported a retrospective study of 4457 women who were divided into normal BMI group (18.5 kg/m2–24.9 kg/m2) and high BMI group (≥25 kg/m2) undergoing 4611 IVF treatment cycles with frozen embryo transfer (FET). We found the high BMI group originally had the poor oocytes performance, but after FET they got the similar pregnancy outcomes as the normal BMI group. Then under FET we analyzed the IVF outcomes of our new progestin-primed ovary stimulation (PPOS) protocol, indicating that the hMG + MPA (4 or 10 mg/d) groups had the obvious better pregnancy results than the conventional short group in the high BMI group, and binary logistic regression analysis showed the hMG + MPA (10 mg/d) group was associated with better pregnancy outcomes than the hMG + MPA (4 mg/d) group. These results indicate PPOS - hMG + MPA (10 mg/d) combined with FET might be a new potential treatment choice for the high BMI women undergoing IVF treatments.
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