Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial.
Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial.
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双歧杆菌益生菌对慢性牙周炎治疗的影响：一项随机临床试验。
DOI：
10.1111/jcpe.12995
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发表时间：
2018-10
影响因子：
6.7
通讯作者：
Messora MR
中科院分区：
文献类型：
--
作者：
Invernici MM;Salvador SL;Silva PHF;Soares MSM;Casarin R;Palioto DB;Souza SLS;Taba M Jr;Novaes AB Jr;Furlaneto FAC;Messora MR
这项随机安慰剂对照临床试验评估了动物双歧杆菌亚种乳酸菌（B. lactis）HN 019益生菌含片作为泛发性慢性牙周炎患者洁治和根面平整（SRP）的辅助剂。招募了41名慢性牙周炎患者，并在基线（SRP前）和SRP后30天和90天进行临床、免疫学和微生物监测。将所有患者随机分配至试验组（SRP +益生菌，n = 20）或对照组（SRP +安慰剂，n = 21）。益生菌含片每天使用两次，持续30天。对数据进行统计学分析。在90天时，试验组的探测囊袋深度减少，临床附着力增加显著高于对照组。与对照组相比，试验组的红色和橙子复合体的牙周病原体也明显减少，促炎细胞因子水平也较低。在30天和90天时，只有试验组显示龈下生物膜上的乳酸B杆菌HN 019 DNA拷贝数增加。使用乳酸B. lactis HN 019作为SRP的辅助剂，可促进慢性牙周炎治疗中的额外临床、微生物学和免疫学获益（NCT 03408548）。
This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis. Forty‐one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90 days after SRP. All patients were randomly assigned to a Test (SRP + Probiotic, n = 20) or Control (SRP + Placebo, n = 21) group. The probiotic lozenges were used twice a day for 30 days. The data were statistically analysed. The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90 days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of B. lactis HN019 DNA copies on subgingival biofilm at 30 and 90 days. The use of B. lactis HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548).
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Keystone-Pathogen假设。
DOI：
10.1038/nrmicro2873
发表时间：
2012-10
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5
作者：
Gillor O;Etzion A;Riley MA
通讯作者：
Riley MA
影响因子：
4.5
作者：
Devine DA;Marsh PD;Meade J
通讯作者：
Meade J
影响因子：
4.5
作者：
Mdala I;Olsen I;Haffajee AD;Socransky SS;de Blasio BF;Thoresen M
通讯作者：
Thoresen M
影响因子：
4.3
作者：
Ince, Gizem;Gursoy, Hare;Yilmaz, Selcuk
通讯作者：
Yilmaz, Selcuk