Characterization of inhalable endotoxin, glucan, and dust exposures in Iowa farmers.
Characterization of inhalable endotoxin, glucan, and dust exposures in Iowa farmers.
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DOI：
10.1016/j.ijheh.2020.113525
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发表时间：
2020-07
影响因子：
6
通讯作者：
Friesen MC
中科院分区：
文献类型：
--
作者：
Sauvé JF;Locke SJ;Josse PR;Stapleton EM;Metwali N;Altmaier RW;Andreotti G;Thorne PS;Hofmann JN;Beane Freeman LE;Friesen MC
根据替代指标，观察到的农民肺癌患病率下降的部分原因是接触有机粉尘和内毒素。为了超越这些病因学研究的替代因素，我们对爱荷华州农民基于任务和时间加权平均 (TWA) 的可吸入内毒素、(1→3)-β-D-葡聚糖和灰尘暴露进行了表征。我们在 2015 年和 2016 年的 69 个样本日内从 32 个农民那里收集了 320 个个人可吸入粉尘样本。使用 Button 气溶胶采样器收集样本，并使用动态显色阿米巴细胞裂解物测定法分析内毒素，并使用鲎终点测定法分析 (1→3)-β-D-葡聚糖。我们使用线性混合效应模型评估了生物气溶胶浓度与选定任务和农场特征之间的关系。垫料工作、生猪处理以及在谷仓/限制建筑、粮仓和谷物升降机中的工作与较高的内毒素暴露有关。我们发现内毒素浓度升高和动物数量增加之间存在单调趋势。垫料工作、清洁和饲料/谷物储存工作与较高的 (1→3)-β-D-葡聚糖浓度相关。任务的中位浓度范围为内毒素的 400 倍、(1→3)-β-D-葡聚糖的 600 倍、可吸入粉尘的 8 倍。 TWA 暴露的内毒素和葡聚糖浓度之间的 Pearson 相关性为 0.22，任务样本的相关性为 0.56。影响生物气溶胶浓度的暴露因素的这种特征可以支持开发精细的生物气溶胶暴露指标，用于未来对农民癌症和其他健康结果的病因分析。
The observed deficit of lung cancer in farmers has been partly attributed to exposure to organic dusts and endotoxins based largely on surrogate metrics. To move beyond these surrogates for etiologic studies, we characterized task-based and time-weighted average (TWA) exposure to inhalable endotoxin, (1→3)-β-D-glucan, and dust in Iowa farmers. We collected 320 personal inhalable dust samples from 32 farmers during 69 sample days in 2015 and 2016. Samples were collected using Button aerosol samplers and analyzed for endotoxin using a kinetic chromogenic amebocyte lysate assay, and for (1→3)-β-D-glucan using a Limulus endpoint assay. We assessed relationships between bioaerosol concentrations and selected tasks and farm characteristics using linear mixed-effects models. Bedding work, hog handling, and working in barn/confinement buildings, grain bins, and grain elevators were associated with higher endotoxin exposure. We found a monotonic trend between higher endotoxin concentrations and increasing number of animals. Bedding work, cleaning, and feed/grain storage work were associated with higher (1→3)-β-D-glucan concentrations. The median concentrations by task spanned a 400-fold range for endotoxin, a 600-fold range for (1→3)-β-D-glucan, and an 8-fold range for inhalable dust. Pearson correlations between endotoxin and glucan concentrations were 0.22 for TWA exposure and 0.56 for task samples. This characterization of exposure factors that influence bioaerosol concentrations can support the development of refined bioaerosol exposure metrics for future etiologic analyses of cancer and other health outcomes in farmers.
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DOI：
10.1080/15287394.2015.1091414
发表时间：
2015
期刊：
Journal of toxicology and environmental health. Part A
影响因子：
--
作者：
Hofmann JN;Beane Freeman LE;Lynch CF;Andreotti G;Thomas KW;Sandler DP;Savage SA;Alavanja MC
通讯作者：
Alavanja MC
影响因子：
14.2
作者：
Heederik, Dick;von Mutius, Erika
通讯作者：
von Mutius, Erika
影响因子：
--
作者：
Halstensen, Anne Straumfors;Heldal, Kari Kulvik;Eduard, Wijnand
通讯作者：
Eduard, Wijnand
影响因子：
2
作者：
Cyprowski, Marcin;Buczynska, Alina;Szadkowska-Stanczyk, Irena
通讯作者：
Szadkowska-Stanczyk, Irena
影响因子：
10.3
作者：
Astrakianakis, George;Seixas, Noah S.;Checkoway, Harvey
通讯作者：
Checkoway, Harvey