Running exercise mitigates the negative consequences of chronic stress on dorsal hippocampal long-term potentiation in male mice.
Running exercise mitigates the negative consequences of chronic stress on dorsal hippocampal long-term potentiation in male mice.
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DOI：
10.1016/j.nlm.2018.01.008
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发表时间：
2018-03
影响因子：
2.7
通讯作者：
Edwards JG
中科院分区：
文献类型：
--
作者：
Miller RM;Marriott D;Trotter J;Hammond T;Lyman D;Call T;Walker B;Christensen N;Haynie D;Badura Z;Homan M;Edwards JG
在海马体中，学习和记忆可能是由突触可塑性（称为长时程增强（LTP））介导的。虽然慢性间歇性压力呈负相关，而运动与 LTP 诱导呈正相关，但我们研究了运动与压力同时发生时是否可以减轻压力对 LTP 的负面影响。将小鼠分为四组：无压力久坐组、无压力运动组、有压力运动组、有压力久坐组。对脑切片进行的现场电生理学证实，与对照组相比，单独的压力显着降低了背侧 CA1 海马的 LTP，而单独的运动则增加了 LTP。有压力的运动小鼠表现出的 LTP 显着高于仅承受压力的小鼠，但与久坐的无压力小鼠没有差异。 ELISA 表明，与没有应激的小鼠相比，应激小鼠的皮质酮有所增加。此外，使用径向臂迷宫来检查 6 周的压力和/或运动期间记忆的行为变化。运动小鼠组在第 2 周犯的错误较少。使用 RT-qPCR 检测四组中应激和运动途径成分的 mRNA 表达。检测到以下靶标表达的显着变化：BDNF、TrkB、糖皮质激素、盐皮质激素和多巴胺 5 受体。总的来说，当两者同时发生时，运动可以减轻压力对海马功能的一些负面影响。
In the hippocampus, learning and memory are likely mediated by synaptic plasticity, known as long-term potentiation (LTP). While chronic intermittent stress is negatively correlated, and exercise positively correlated to LTP induction, we examined whether exercise could mitigate the negative consequences of stress on LTP when co-occurring with stress. Mice were divided into four groups: sedentary no stress, exercise no stress, exercise with stress, and sedentary with stress. Field electrophysiology performed on brain slices confirmed that stress alone significantly reduced dorsal CA1 hippocampal LTP and exercise alone increased LTP compared to controls. Exercise with stress mice exhibited LTP that was significantly greater than mice undergoing stress alone but were not different from sedentary no stress mice. An ELISA illustrated increased corticosterone in stressed mice compared to no stress mice. In addition, a radial arm maze was used to examine behavioral changes in memory during 6 weeks of stress and/or exercise. Exercised mice groups made fewer errors in week 2. RT-qPCR was used to examine the mRNA expression of components in the stress and exercise pathways in the four groups. Significant changes in the expression of the following targets were detected: BDNF, TrkB, glucocorticoid, mineralocorticoid, and dopamine 5 receptors. Collectively, exercise can mitigate some of the negative impact stress has on hippocampal function when both occur concurrently.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
2
作者：
Baker, KB;Kim, JJ
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3.2
作者：
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通讯作者：
Day HE
影响因子：
3.3
作者：
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通讯作者：
Cotman, C. W.
影响因子：
2.9
作者：
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通讯作者：
Duman, Ronald S.