Ventral pallidal regulation of motivated behaviors and reinforcement.
Ventral pallidal regulation of motivated behaviors and reinforcement.
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DOI：
10.3389/fncir.2023.1086053
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发表时间：
2023
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
腹侧基底节的相互连接的核团长期以来被认为是动机行为的关键调节因素，该回路的功能障碍与情绪和物质使用障碍密切相关。腹侧苍白球(Vp)是腹侧基底节的一个中心节点，最近的研究揭示了复杂的Vp细胞异质性以及对奖赏、厌恶、动机和药物寻找行为的细胞和回路特异性调节。尽管经典地认为VP是这个回路的继电器和输出结构，但新出现的数据表明，VP是一个广泛的网络中的中心枢纽，用于奖励处理和动机调节，其范围超出了经典定义的基底节边界。与伏隔上游核神经元相比，VP神经元在时间上反应更快，表现出更高级的奖励编码和预测错误处理，并调节腹侧中脑多巴胺系统的活动。这篇综述将总结文献中的最新发现，并提供关于复杂的细胞异质性以及细胞和回路特异性调节动机行为的最新进展，以及VP对情绪和物质使用障碍的强化。此外，我们将讨论压力和药物暴露改变VP功能和产生神经精神障碍易感性的机制。最后，我们将概述未回答的问题，并确定未来必要的研究方向，以进一步阐明VP神经元在调节动机行为中的中心作用。意义：过去十年的研究揭示了VP在奖赏处理和动机行为调控中复杂的细胞和电路特有的作用。使用细胞和电路特定的询问策略获得的新颖见解导致了我们对这一区域的理解的重大转变。在这里，我们提供了对VP的全面回顾，其中我们结合了新的发现和现有的文献，并强调了VP作为调节动机、奖励和厌恶的神经系统的关键作用。此外，我们还讨论了在神经精神障碍动物模型中VP的功能障碍。
The interconnected nuclei of the ventral basal ganglia have long been identified as key regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in mood and substance use disorders. The ventral pallidum (VP) is a central node of the ventral basal ganglia, and recent studies have revealed complex VP cellular heterogeneity and cell- and circuit-specific regulation of reward, aversion, motivation, and drug-seeking behaviors. Although the VP is canonically considered a relay and output structure for this circuit, emerging data indicate that the VP is a central hub in an extensive network for reward processing and the regulation of motivation that extends beyond classically defined basal ganglia borders. VP neurons respond temporally faster and show more advanced reward coding and prediction error processing than neurons in the upstream nucleus accumbens, and regulate the activity of the ventral mesencephalon dopamine system. This review will summarize recent findings in the literature and provide an update on the complex cellular heterogeneity and cell- and circuit-specific regulation of motivated behaviors and reinforcement by the VP with a specific focus on mood and substance use disorders. In addition, we will discuss mechanisms by which stress and drug exposure alter the functioning of the VP and produce susceptibility to neuropsychiatric disorders. Lastly, we will outline unanswered questions and identify future directions for studies necessary to further clarify the central role of VP neurons in the regulation of motivated behaviors. Significance: Research in the last decade has revealed a complex cell- and circuit-specific role for the VP in reward processing and the regulation of motivated behaviors. Novel insights obtained using cell- and circuit-specific interrogation strategies have led to a major shift in our understanding of this region. Here, we provide a comprehensive review of the VP in which we integrate novel findings with the existing literature and highlight the emerging role of the VP as a linchpin of the neural systems that regulate motivation, reward, and aversion. In addition, we discuss the dysfunction of the VP in animal models of neuropsychiatric disorders.
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影响因子：
3.4
作者：
Ahrens AM;Ferguson LM;Robinson TE;Aldridge JW
通讯作者：
Aldridge JW
影响因子：
6.1
作者：
Chen, JC;Liang, KW;Chiang, YC
通讯作者：
Chiang, YC
DOI：
10.1523/jneurosci.6491-10.2011
发表时间：
2011-05-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ambroggi F;Ghazizadeh A;Nicola SM;Fields HL
通讯作者：
Fields HL
影响因子：
25
作者：
Bock, Roland;Shin, J. Hoon;Kaplan, Alanna R.;Dobi, Alice;Markey, Eric;Kramer, Paul F.;Gremel, Christina M.;Christensen, Christine H.;Adrover, Martin F.;Alvarez, Veronica A.
通讯作者：
Alvarez, Veronica A.
影响因子：
2.5
作者：
Bengtson, CP;Lee, DJ;Osborne, PB
通讯作者：
Osborne, PB