Early and late age of seizure onset have a differential impact on brain resting-state organization in temporal lobe epilepsy.
Early and late age of seizure onset have a differential impact on brain resting-state organization in temporal lobe epilepsy.
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DOI：
10.1007/s10548-014-0366-6
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发表时间：
2015-01
期刊：
影响因子：
2.7
通讯作者：
Tracy, Joseph I.
中科院分区：
文献类型：
--
作者：
Doucet, Gaelle E.;Sharan, Ashwini;Pustina, Dorian;Skidmore, Christopher;Sperling, Michael R.;Tracy, Joseph I.
颞叶癫痫(TLE)与延伸至整个大脑的异常有关。虽然癫痫发作的年龄(SO)对大脑的可塑性有很大的影响，但它对静息状态下大脑连通性的影响尚不清楚，特别是在与内侧颞叶硬化症(MTS)等因素相互作用时。在此背景下，我们使用图论方法研究了50名接受静息状态fMRI扫描的TLE患者的全脑和区域功能连接(FC)组织，并与健康对照组进行了比较。我们首先根据有无MTS对TLE患者进行分类。然后，我们根据SO患者的年龄将其分为两个亚组(SO早期和晚期)。结果显示，与对照组相比，与对照组相比，无论SO和MTS的年龄如何，患者的全脑差异都减少了功能分离，增加了整合。在局部水平，我们发现，即使在没有MTS的情况下，发作期海马区的连通性仍然是早期SO最严重的受损。重要的是，我们发现SO的年龄对全脑和局部静息状态FC的影响依赖于MTS的存在。总体而言，我们的结果强调了在研究TLE中静息状态活动时研究SO年龄的影响的重要性，因为这一因素导致了全球和局部水平上网络模块化和连通性的不同扰动，对区域可塑性和适应性组织具有不同的含义。本文的在线版本(doi：10.1007/s10548-0140366-6)包含补充材料，授权用户可以使用。
Temporal lobe epilepsy (TLE) is associated with abnormalities which extend into the entire brain. While the age of seizure onset (SO) has a large impact on brain plasticity, its effect on brain connectivity at rest remains unclear, especially, in interaction with factors such as the presence of mesial temporal sclerosis (MTS). In this context, we investigated whole-brain and regional functional connectivity (FC) organization in 50 TLE patients who underwent a resting-state fMRI scan, in comparison to healthy controls, using graph-theory measures. We first classified TLE patients according to the presence of MTS or not. Then, we categorized the patients based on their age of SO into two subgroups (early or late age of SO). Results revealed whole-brain differences with both reduced functional segregation and increased integration in the patients, regardless of the age of SO and MTS, relative to the controls. At a local level, we revealed that the connectivity of the ictal hippocampus remains the most impaired for an early SO, even in the absence of MTS. Importantly, we showed that the impact of age of SO on whole-brain and regional resting-state FC depends on the presence of MTS. Overall, our results highlight the importance of investigating the effect of age of SO when examining resting-state activity in TLE, as this factor leads different perturbations of network modularity and connectivity at the global and local level, with different implications for regional plasticity and adaptive organization. The online version of this article (doi:10.1007/s10548-014-0366-6) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
作者：
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
通讯作者：
Zang YF
影响因子：
2.2
作者：
Stretton J;Thompson PJ
通讯作者：
Thompson PJ
影响因子：
4.8
作者：
Doucet, Gaelle;Osipowicz, Karol;Sharan, Ashwini;Sperling, Michael R.;Tracy, Joseph I.
通讯作者：
Tracy, Joseph I.
影响因子：
11.2
作者：
Helmstaedter, C;Kurthen, M;Elger, CE
通讯作者：
Elger, CE
DOI：
10.1073/pnas.0601602103
发表时间：
2006-06-06
影响因子：
11.1
作者：
Newman, M. E. J.
通讯作者：
Newman, M. E. J.