Frontal lobe function in temporal lobe epilepsy.
Frontal lobe function in temporal lobe epilepsy.
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DOI：
10.1016/j.eplepsyres.2011.10.009
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发表时间：
2012-01
影响因子：
2.2
通讯作者：
Thompson PJ
中科院分区：
文献类型：
--
作者：
Stretton J;Thompson PJ
颞叶癫痫（TLE）通常与长期记忆障碍有关。额叶支持高级认知，包括执行技能和对日常生活功能至关重要的工作记忆。这些功能的缺陷在TLE中越来越多地被报道。来自神经心理学和神经影像学文献的证据表明，在TLE的存在下，执行功能和工作记忆都受到损害。关于执行障碍，特别关注的是通过威斯康星卡片分类任务来衡量的设置转移。其他独立的执行功能，如决策和心理理论，似乎也很脆弱，但很少受到关注。关于工作记忆，内侧颞叶结构似乎具有更关键的作用，但有证据表明海马依赖和独立的过程。基础病理和发作扩散的相对作用可能对TLE的认知表型和轨迹有相当大的影响。因此，确定TLE患者额叶功能障碍的性质对预后和手术治疗具有重要的临床意义。纵向神经心理学和神经影像学研究评估TLE患者术前和术后额叶功能将进一步提高我们的认识。
Temporal lobe epilepsy (TLE) is typically associated with long-term memory dysfunction. The frontal lobes support high-level cognition comprising executive skills and working memory that is vital for daily life functioning. Deficits in these functions have been increasingly reported in TLE. Evidence from both the neuropsychological and neuroimaging literature suggests both executive function and working memory are compromised in the presence of TLE. In relation to executive impairment, particular focus has been paid to set shifting as measured by the Wisconsin Card Sorting Task. Other discrete executive functions such as decision-making and theory of mind also appear vulnerable but have received little attention. With regard to working memory, the medial temporal lobe structures appear have a more critical role, but with emerging evidence of hippocampal dependent and independent processes. The relative role of underlying pathology and seizure spread is likely to have considerable bearing upon the cognitive phenotype and trajectory in TLE. The identification of the nature of frontal lobe dysfunction in TLE thus has important clinical implications for prognosis and surgical management. Longitudinal neuropsychological and neuroimaging studies assessing frontal lobe function in TLE patients pre- and postoperatively will improve our understanding further.
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影响因子：
5.3
作者：
Axmacher, Nikolai;Mormann, Florian;Fell, Juergen
通讯作者：
Fell, Juergen
影响因子：
2.6
作者：
Giovagnoli, AR
通讯作者：
Giovagnoli, AR
影响因子：
2.5
作者：
Berg, Esta A.
通讯作者：
Berg, Esta A.
DOI：
10.1016/j.yebeh.2009.05.012
发表时间：
2009-08
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Dabbs K;Jones J;Seidenberg M;Hermann B
通讯作者：
Hermann B
影响因子：
3.5
作者：
CAVE, CB;SQUIRE, LR
通讯作者：
SQUIRE, LR