Environmental Endocrine Disruptors and Endometriosis.
Environmental Endocrine Disruptors and Endometriosis.
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DOI：
10.1007/978-3-030-51856-1_4
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Bruner-Tran KL
中科院分区：
文献类型：
--
作者：
Rumph JT;Stephens VR;Archibong AE;Osteen KG;Bruner-Tran KL
工业化的结果是，成千上万的人造化学品被开发出来，很少有在商业使用之前经过严格的安全评估。普遍暴露于这些化合物，其中许多作为内分泌干扰化学品（EDCs），已被认为是许多疾病（包括子宫内膜异位症）发病率增加的一个因素。子宫内膜异位症，即子宫内膜腺体和间质在子宫外的存在，是育龄妇女的常见疾病。虽然一些基于人群的研究表明，暴露于环境中的内分泌干扰物可能会影响妇女患上这种疾病的风险，但流行病学评估的结果往往是模棱两可的。然而，子宫内膜异位症的发展是一个随着时间推移而发生的过程;因此，对有毒物质身体负荷的单一评估不能明确地与疾病的病因联系起来。出于这个原因，许多研究人员利用各种啮齿动物模型来研究特定的内分泌干扰物对实验性子宫内膜异位症发展的影响。这些研究确定了多种能够影响啮齿动物异位组织建立和/或存活所需的生理过程的化学物质，表明这些化合物也可能引起女性的关注。重要的是，这些模型作为有用的工具，探索策略，可以防止EDC暴露后的不良后果。
As a consequence of industrialization, thousands of man-made chemicals have been developed with few undergoing rigorous safety assessment prior to commercial use. Ubiquitous exposure to these compounds, many of which act as endocrine-disrupting chemicals (EDCs), has been suggested to be one factor in the increasing incidence of numerous diseases, including endometriosis. Endometriosis, the presence of endometrial glands and stroma outside the uterus, is a common disorder of reproductive-age women. Although a number of population-based studies have suggested that exposure to environmental EDCs may affect a woman’s risk of developing this disease, results of epidemiology assessments are often equivocal. The development of endometriosis is, however, a process occurring over time; thus, a single assessment of toxicant body burden cannot definitively be linked to causation of disease. For this reason, numerous investigators have utilized a variety of rodent models to examine the impact of specific EDCs on the development of experimental endometriosis. These studies identified multiple chemicals capable of influencing physiologic processes necessary for the establishment and/or survival of ectopic tissues in rodents, suggesting that these compounds may also be of concern for women. Importantly, these models serve as useful tools to explore strategies that may prevent adverse outcomes following EDC exposure.
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