A preliminary study on the relationship between sleep, depression and cardiovascular dysfunction in a 4 sample population.
A preliminary study on the relationship between sleep, depression and cardiovascular dysfunction in a 4 sample population.
复制标题
DOI：
10.1016/j.ijcha.2021.100814
复制
发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Deldin PJ
中科院分区：
文献类型：
--
作者：
Bilbao AV;Goldschmied J;Jang A;Ehrmann D;Kaplish N;Pitt B;Arnedt T;Sen S;Dalack G;Deldin PJ
在文献中，重度抑郁症（MDD）与心血管功能障碍患者预后较差有关，尽管这种关系的机制尚不清楚。潜在的睡眠呼吸障碍（SDB）可以作为解释这种效应的潜在候选，因为它对炎症激活和一氧化氮（NO）生物利用度的降低具有下游作用，这两者都被证明有助于MDD和心血管疾病（CVD）的病理生理。本研究利用夜间多导睡眠图和炎症小组来检查对照组参与者和诊断为SDB、MDD、SDB和MDD的患者的心血管功能障碍和睡眠困难之间的联系。结果表明，在MDD患者中，睡眠障碍与一氧化氮合成抑制剂对称二甲基精氨酸（SDMA）之间存在强烈的正相关，表明SDMA介导的NO失调与MDD患者CVD发病机制之间存在联系。此外，睡眠不足，一种以气流部分减少为特征的睡眠障碍形式，被发现在SDB和mdd患者心血管功能障碍之间的关系中起重要作用。本研究结果表明，需要在MDD人群中广泛筛查SDB以发现CVD易感性，并提供SDMA作为MDD患者CVD治疗的新潜在靶点。
Major Depressive Disorder (MDD) has been linked in the literature to poorer prognosis in patients with cardiovascular dysfunction, although the mechanisms of this relationship remain unclear. Underlying Sleep Disordered Breathing (SDB) serves as a potential candidate to explain this effect due to its downstream effects on inflammatory activation and decreased nitric oxide (NO) bioavailability, both of which have been shown to contribute to the pathophysiology of both MDD and cardiovascular disease (CVD). This study utilizes overnight polysomnography and an inflammation panel to examine the links between cardiovascular dysfunction and sleep difficulties in control participants and patients diagnosed with SDB only, MDD only, and both SDB and MDD. Results demonstrate a strong positive relationship between sleep dysfunction and the nitric oxide synthesis inhibitor Symmetric Dimethyl Arginine (SDMA) in the MDD-only cohort, suggesting a link between SDMA-mediated NO dysregulation and CVD pathogenesis in individuals with MDD. Additionally, hypopneas, a form of sleep impairment characterized by partial reduction of airflow, were found to play a significant role in the relationship between SDB and cardiovascular dysfunction in MDD-only patients. Results of this study demonstrate the need for widespread screening for SDB in MDD populations to detect predisposition to CVD, and also offer SDMA as a new potential target for CVD treatment in individuals with MDD.
登录
查看更多内容
影响因子：
6.9
作者：
Dinan, Timothy G.
通讯作者：
Dinan, Timothy G.
影响因子：
158.5
作者：
YOUNG, T;PALTA, M;BADR, S
通讯作者：
BADR, S
影响因子：
6.6
作者：
Ali-Sisto, Toni;Tolmunen, Tommi;Lehto, Soili M.
通讯作者：
Lehto, Soili M.
影响因子：
168.9
作者：
Valkonen, VP;Päivä, H;Laaksonen, R
通讯作者：
Laaksonen, R
影响因子：
39.3
作者：
Davidson, Karina W.;Mostofsky, Elizabeth;Whang, William
通讯作者：
Whang, William