Lesions of the fasciculus retroflexus alter footshock-induced cFos expression in the mesopontine rostromedial tegmental area of rats.
Lesions of the fasciculus retroflexus alter footshock-induced cFos expression in the mesopontine rostromedial tegmental area of rats.
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DOI：
10.1371/journal.pone.0060678
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Shepard PD
中科院分区：
文献类型：
--
作者：
Brown PL;Shepard PD
中脑多巴胺神经元是动力和强化基础回路的重要组成部分。它们被奖赏或奖赏预测线索激活，被奖赏遗漏抑制。外侧缰核(LHB)是一种与中脑多巴胺神经元形成相互联系的上皮层结构，它表现出相反的反应，被奖赏遗漏或厌恶刺激激活，并被奖赏预测线索抑制。据推测，缰核对中脑多巴胺神经元的输入是通过涉及GABA能中脑桥脑头内侧被盖区的前馈抑制通路来传递的。在这里，我们表明，暴露于低强度足部电击(4次，0.5毫安电击，持续20分钟)可以诱导大鼠被盖旋转内侧区CFos的表达，这种影响可以通过损伤缰核的主要输出通路--反屈肌束来阻止。在外侧缰核的内侧部分也观察到CFos的表达，该区域通过fr和丘脑室旁核接受密集的DA神经支配，这是一个也接受多巴胺能输入的应激敏感区域。高强度足部电击(120，0.8 mA电击40min)也可增加被盖旋转内侧区、外侧缰核内侧和外侧侧以及室旁丘脑CFos的表达。与低强度足底电击不同的是，fr损伤不会改变旋转内侧被盖区CFos表达的增加，这表明在暴露于高度厌恶刺激期间，非缰核输入起到了作用。这些数据证实外侧缰核参与调节被盖区旋转内侧区神经元对轻微厌恶刺激的反应，并提示多巴胺的输入可能有助于足底电击诱导外侧缰核CFos表达的激活。
Midbrain dopamine neurons are an essential part of the circuitry underlying motivation and reinforcement. They are activated by rewards or reward-predicting cues and inhibited by reward omission. The lateral habenula (lHb), an epithalamic structure that forms reciprocal connections with midbrain dopamine neurons, shows the opposite response being activated by reward omission or aversive stimuli and inhibited by reward-predicting cues. It has been hypothesized that habenular input to midbrain dopamine neurons is conveyed via a feedforward inhibitory pathway involving the GABAergic mesopontine rostromedial tegmental area. Here, we show that exposing rats to low-intensity footshock (four, 0.5 mA shocks over 20 min) induces cFos expression in the rostromedial tegmental area and that this effect is prevented by lesions of the fasciculus retroflexus, the principal output pathway of the habenula. cFos expression is also observed in the medial portion of the lateral habenula, an area that receives dense DA innervation via the fr and the paraventricular nucleus of the thalamus, a stress sensitive area that also receives dopaminergic input. High-intensity footshock (120, 0.8 mA shocks over 40 min) also elevates cFos expression in the rostromedial tegmental area, medial and lateral aspects of the lateral habenula and the paraventricular thalamus. In contrast to low-intensity footshock, increases in cFos expression within the rostromedial tegmental area are not altered by fr lesions suggesting a role for non-habenular inputs during exposure to highly aversive stimuli. These data confirm the involvement of the lateral habenula in modulating the activity of rostromedial tegmental area neurons in response to mild aversive stimuli and suggest that dopamine input may contribute to footshock- induced activation of cFos expression in the lateral habenula.
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缰核：脊椎动物大脑中保守的不对称中继站。
DOI：
10.1098/rstb.2008.0213
发表时间：
2009-04-12
影响因子：
6.3
作者：
Bianco, Isaac H.;Wilson, Stephen W.
通讯作者：
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影响因子：
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作者：
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通讯作者：
Hikosaka, Okihide
影响因子：
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作者：
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通讯作者：
JEAUGEY, L
影响因子：
2.9
作者：
GOTTESFELD, Z
通讯作者：
GOTTESFELD, Z
影响因子：
2.9
作者：
Greenwood, BN;Foley, TE;Fleshner, M
通讯作者：
Fleshner, M