The effect of low b-values on the intravoxel incoherent motion derived pseudodiffusion parameter in liver.
The effect of low b-values on the intravoxel incoherent motion derived pseudodiffusion parameter in liver.
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DOI：
10.1002/mrm.25109
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发表时间：
2015-01
影响因子：
3.3
通讯作者：
Schmainda, Kathleen M.
中科院分区：
文献类型：
--
作者：
Cohen, Alexander D.;Schieke, Moira C.;Hohenwalter, Mark D.;Schmainda, Kathleen M.
检查正常肝脏中低b值（0<B<50 s/mm 2）对计算体素内非相干运动（IVIM）导出的伪扩散参数的影响。进行模拟以检查添加低b值对伪扩散参数的影响。将低b值累积添加到分布中，并使用不同的伪扩散值生成IVIM信号。加入高斯噪声后，将信号与IVIM模型进行拟合，并将模拟值与真实值进行比较。此外，8名对照受试者的肝脏成像使用磁共振触发DWI。在有和没有低b值的情况下计算假扩散并进行比较。当低b值不包括在b值分布中时，伪扩散倾向于被低估，如通过模拟预测并通过体内成像证实的。随着添加更多低b值，离群值的数量也减少。总之，本研究表明，当分布中包含的低b值（0<B<50 s/mm 2）太少时，肝脏中的假扩散往往被低估。因此，建议在进行肝脏IVIM研究时至少包括两个低b值。
To examine the effect of low b-values (0<b<50 s/mm2) on the calculation of the intravoxel incoherent motion (IVIM) derived pseudodiffusion parameter in the normal liver. Simulations were performed to examine the effects of adding low b-values on the pseudodiffusion parameter. Low b-values were cumulatively added to the distribution and the IVIM signal was generated with varying pseudodiffusion values. The signal was fit with the IVIM model after the addition of Gaussian noise, and the simulated values were compared to the true values. In addition, the livers of eight control subjects were imaged using respiratory-triggered DWI. Pseudodiffusion was calculated with and without low b-values and compared. Pseudodiffusion tended to be underestimated when low b-values were not included in the b-value distribution as predicted by simulations and confirmed with in vivo imaging. The number of outlier values was also reduced as more low b-values were added. In conclusion, this study showed pseudodiffusion in the liver tended to be underestimated when too few low b-values (0<b<50 s/mm2) were included in the distribution. Therefore, it is recommended to include at least two low b-values when performing liver IVIM studies.
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